Platelet rich fibrin (PRF) has been widely used in regenerative dentistry since it provides plenty amount of growth factors that enhance wound healing and tissue regeneration. Platelet derived growth factor-BB (PDGF-BB) is a growth factor with essential functions such as regulation of cell migration, proliferation, and differentiation. This study aims to evaluate the efficacy of PRF in improving the clinical periodontal parameters and GCF level of PDGF-BB.
Split mouth randomized clinical trial is the design of the study. 12 periodontitis patients with 24 opposite shallow periodontal pockets (4-6 mm in depth) will be selected. Randomization in this study will be achieved using toss of coin method in which periodontal pockets will be designated either control site or test site. PRF will be used as an adjunct to scaling and root planing to treat the test sites. While control sites were treated by scaling and root planing only. Clinal periodontal parameters were recorded and GCF level of PDGF-BB will be measured at baseline and1- and 3- month follow-up visits to evaluate the healing response to the treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
12
Split mouth randomized clinical trial will be the design of the study. 12 periodontitis patients with 24 opposite shallow periodontal pockets (4-6 mm in depth) will be selected. Randomization in this study will be achieved using toss of coin method in which periodontal pockets were designated either control site or test site. PRF will be used as an adjunct to scaling and root planing to treat the test sites. While control sites will be treated by scaling and root planing only. Clinal periodontal parameters will be recorded and GCF level of PDGF-BB will be measured at baseline and1- and 3- month follow-up visits to evaluate the healing response to the treatment.
Change in Clinical attachment level
Using UNC-15 periodontal probe measured in mm
Time frame: Change from baseline to 1-month and change from baseline to 3-month
Change in Periodontal pocket depth measured in mm
Using UNC-15 periodontal probe measured in mm
Time frame: Change from baseline to 1-month and change from baseline to 3-month
Change in plaque index
Using Sinless and Loe 1964 plaque index scores
Time frame: Change from baseline to 1-month and change from baseline to 3-month
Change in bleeding on probing percentage
Using UNC-15 periodontal probe
Time frame: Change from baseline to 1-month and change from baseline to 3-month
Change in GCF level of platelet derived growth factor
Using periocol paper to collect GCF and analysed by ELISA test
Time frame: Change from baseline to 1-month and change from baseline to 3-month
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