10E8.4/iMab Bispecific Antibody and VRC07-523LS Monoclonal Antibody in HIV-infected Adults

Inclusion Criteria: 1. Able to read and write in Kiswahili and/or English 2. Able and willing to provide written informed consent 3. Passes Test of Understanding (TOU) 4. Aged 18-50 years, inclusive 5. Antiretroviral Therapy (ART)-naïve or no ART for \> 24 weeks at the time of screening 6. HIV RNA 1,000-100,000 copies/mL 7. CD4 ≥ 500 cells/mm3 8. Laboratory criteria at screening within protocol-specified limits for blood, chemistry and urinalysis 9. Willing and able to participate in study visits and procedures for up to 50 weeks 10. Willing and able to begin ART as directed during the study 11. Willing and able to use barrier protection during sex with partners without HIV or partners with unknown HIV status throughout Step 1 and until viral suppression \<200 copies/mL is confirmed in Step 2 12. Willing and able to adhere to the following contraception requirements: 1. Participants who are able to become pregnant must agree to use at least one method of highly effective contraception if participating in sexual activity that could lead to pregnancy. This must begin at least 14 days prior to study enrollment. 2. Participants who engage in sexual activity that could lead to their partner becoming pregnant and who are of reproductive potential must agree to use a barrier method of contraception to avoid pregnancy in a sexual partner of reproductive potential. The barrier method must be used for the duration of the study. Exclusion Criteria: 1. Weight \>100 kg 2. Previous receipt of humanized or human monoclonal antibody whether licensed or investigational (other than for the prevention and/or treatment of SARS-CoV2/COVID-19) 3. History of viral failure on two or more ART regimens 4. Planned or anticipated need for enfuvirtide, maraviroc, fostemsavir, or ibalizumab for antiretroviral therapy. 5. AIDS-defining illness, as enumerated by the WHO Stage 3 or 4, within the six months prior to enrollment 6. Ongoing oral thrush 7. Active injection or other recreational drug use within the previous 12 months that, in the opinion of the investigator, would impede the participant's ability to safely and consistently adhere to the study protocol 8. History of a severe allergic reaction with generalized urticaria, angioedema or anaphylaxis in the 2 years prior to enrollment. 9. History of chronic urticaria requiring daily treatment 10. Known active hepatitis B virus infection or positive hepatitis B surface antigen at any time in the past 11. Known active hepatitis C virus infection or positive hepatitis C antibody at any time in the past 12. Untreated syphilis 13. Estimated GFR \< 50 mL/min within the past 90 days 14. Pregnant or breast-feeding 15. Receipt of licensed vaccine or other investigational study agent within 28 days prior to enrollment or any past participation in an investigational HIV vaccine study with receipt of active product 16. Current or planned participation in another interventional clinical trial during the study period, including clinical trials of investigational new drugs or investigating a new application for an approved medication 17. Chronic or recurrent use of medications that modify host immune response, such as oral steroids, parenteral steroids, or cancer chemotherapy (note: locally-acting medications-such as inhaled, topical, or intra-articular steroids-are allowed) 18. Any other chronic or clinically significant medical condition that in the opinion of the investigator would jeopardize the safety or rights of the participant including, but not limited to: diabetes mellitus type I, chronic hepatitis, renal failure; OR clinically significant forms of: drug or alcohol abuse, mental illness, severe asthma, autoimmune disease, decompensated psychiatric disorders, hypertension, heart disease, or cancer 19. Any medications that, in the opinion of the investigator, would preclude intramuscular injections 20. Study site employee