The purpose of this study is to evaluate the effect of BMS-986196 when coadministered with combined hormonal oral contraceptives (ethinyl estradiol \[EE\] and norethindrone \[NET\]) in healthy female participants.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
15
Specified dose on specified days
Specified dose on specified days
Altasciences
Cypress, California, United States
Maximum observed plasma concentration (Cmax)
Time frame: At Day 1 and Day 20
Area under the plasma concentration-time curve from time zero to time of last quantifiable concentration (AUC [0-T])
Time frame: At Day 1 and Day 20
Area under the plasma concentration-time curve from time zero extrapolated to infinite time (AUC [INF])
Time frame: At Day 1 and Day 20
Time of maximum observed plasma concentration (Tmax)
Time frame: At Day 1 and Day 20
Terminal half-life (T-HALF)
Time frame: At Day 1 and Day 20
Apparent total body clearance (CLT/F)
Time frame: At Day 1 and Day 20
Number of participants with Adverse Events (AEs)
Time frame: Up to Day 49
Number of participants with Serious AEs (SAEs)
Time frame: Up to Day 49
Number of participants with clinical laboratory abnormalities
Time frame: Up to Day 49
Number of participants with vital sign abnormalities
Time frame: Up to Day 49
Number of participants with electrocardiogram (ECG) abnormalities
Time frame: Up to Day 49
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Number of participants with physical examination abnormalities
Time frame: Up to Day 49
Number of participants with any abnormal columbia-suicide severity rating scale (C-SSRS)
Time frame: Up to Day 49