Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages.
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer's disease (AD). Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants including those dropped out (5%) were screened and enrolled. The selected participants were treated as a single group without randomization. Evaluated the association between total and differential white blood cell (WBC) counts and AD risk at individual levels after 4 weeks of H2 gas inhalation treatment. Furthermore, evaluation of dementia-related biomarkers such as beta-site APP cleaving enzyme 1 (BACE-1), amyloid beta (Aβ), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor A (VEGF-A), T-tau, monocyte chemotactic protein-1 (MCP-1), and inflammatory cytokines (interleukin-6).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
54
H2 gas inhalation treatment for 4 weeks in on community dwelling adults of various ages
Wonju College of Medicine
Wŏnju, Ganwon-do, South Korea
Wonju Severance Christian Hospital
Wŏnju, Gwando, South Korea
Measurement of white blood cell and its differential counts such as neutrophils (%), basophils (%)
4 weeks treatment of H2 gas inhalation in community dwelling adults of various ages
Time frame: 4 weeks
Measurement of oxidative stress markers such as reactive oxygen species (µM), and nitric oxide (µM)
4 weeks treatment of H2 gas inhalation in community dwelling adults of various ages
Time frame: 4 weeks
Measurement of dementia biomarkers such as brain-derived neurotrophic factor (BDNF ng/mL)
4 weeks treatment of H2 gas treatment
Time frame: 4 weeks
Measurement of dementia biomarkers such as brain-derived neurotrophic factor amyloid beta (Aβ (pg/mL))
4 weeks treatment of H2 gas treatment
Time frame: 4 weeks
Measurement of inflammatory markers such as interleukin 6 (pg/mL)
4 weeks treatment of H2 gas treatment
Time frame: 4 weeks
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