Ciprofol, a novel intravenous general anesthetic with a chemical structure akin to propofol, boasts significantly enhanced potency. It offers a rapid onset, reduced incidence of injection pain, and minor impact on the cardiovascular system. However, clinical research regarding ciprofol's use for anesthesia induction in cardiac surgery remains limited. The investigators want to assesse the safety and effectiveness of ciprofol in cardiac surgery anesthesia
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
80
Patients in ciprofol group 0.3 mg/kg ciprofol for induction of anesthesia
Patients in propofol group received 1.5 mg/kg propofol for induction of anesthesia
Shanghai East Hospital of Tongji University
Shanghai, Shanghai Municipality, China
RECRUITINGMean arterial pressure
an average blood pressure in an individual during a single cardiac cycle
Time frame: 1 second before induction of anesthesia (T1)
Mean arterial pressure
an average blood pressure in an individual during a single cardiac cycle
Time frame: 1 second before tracheal intubation (T2)
Mean arterial pressure
an average blood pressure in an individual during a single cardiac cycle
Time frame: 1 minute after tracheal intubation (T3)
Mean arterial pressure
an average blood pressure in an individual during a single cardiac cycle
Time frame: 5 minutes after tracheal intubation (T4)
Heart beats
the number of times each minute that heart beats
Time frame: 1 second before induction of anesthesia (T1)
Heart beats
the number of times each minute that heart beats
Time frame: 1 second before tracheal intubation (T2)
Heart beats
the number of times each minute that heart beats
Time frame: 1 minute after tracheal intubation (T3)
Heart beats
the number of times each minute that heart beats
Time frame: 5 minutes after tracheal intubation (T4).
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Oxygenation index
a calculation used in intensive care medicine to measure the fraction of inspired oxygen (FiO2) and its usage within the body.
Time frame: 1 second before induction of anesthesia (T1)
Oxygenation index
a calculation used in intensive care medicine to measure the fraction of inspired oxygen (FiO2) and its usage within the body.
Time frame: 10 minutes after tracheal intubation (T5).
Injection pain
Pain at the injection site when injecting the drug（Evaluation with Visual Analogue Scale）
Time frame: During procedure (When injecting the drug, ask the subject if the injection site is painful)