This study takes amyotrophic lateral sclerosis (ALS) patients as the main research object. Through collecting genetics, imaging and clinical symptoms for Exploratory research, we will construct the gene spectrum of ALS in China, explore unknown pathogenic genes, explore the characteristic image characteristics of ALS, and establish the iPSCs library of ALS, providing resources and basis for the research of pathogenesis and treatment targets of ALS.
This study is a multicenter, prospective registration study that will follow up patients with clinically confirmed and suspected amyotrophic lateral sclerosis for a period of 2 years. A total of 1000 patients will be included to dynamically observe the changes in clinical symptoms and signs, imaging, electrophysiology, biomarkers, biological samples and so on, which will construct a genetic profile of ALS in China, explore the etiology and pathogenesis, and establish an iPSCs library, provide a basis for finding treatment targets.
Study Type
OBSERVATIONAL
Enrollment
1,000
All ALS patients included in this group.
Beijing Tiantan Hospital
Beijing, China
Gene Mutation Characteristics of ALS in Chinese
Constructing a Chinese ALS genetic information database by collecting genetic information from patients.
Time frame: day 1
The disease development of ALS in the Chinese
Record the progress of patients' clinical symptoms from baseline through 2-year follow-up.
Time frame: month 24
Exploring the imaging characteristics of ALS in the Chinese
Record the change of the patient's head MRI from baseline through follow-up every 3 months.
Time frame: day 1, month 3, month 6, month 9, month 12, month 15, month 18, month 21, month 24
Establishing an iPSCs library for ALS in the Chinese
100 fALS and clinically typical sALS were selected. Monocytes were isolated from peripheral blood collected at baseline, and Reprogramming into iPSCs to establish iPSCs library.
Time frame: day 1
Analysis of the correlation between electrophysiology characteristics and imaging characteristics of ALS in Chinese
Record the progression of the disease from an electrophysiological and imaging perspective by conducting electromyography and head MRI every 3 months.
Time frame: day 1, month 3, month 6, month 9, month 12, month 15, month 18, month 21, month 24
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