Evaluation of Some Biochemical Markers of Bone Turnover in Childern and Adolescents With Type 1 Diabetes

Sohag University100 enrolled

Overview

Type 1 diabetes is associated with many longterm complications as retinopathy,neuropathy and nephropathy. Recently, several studies have linked type 1 diabetes to bone fragility.Studies conducted on patients with type 1 diabetes have concluded that bone is negatively affected in type 1 diabetes with impaired bone density,increased fracture risk and impaired bone turnover markers.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Type 1 Diabetes

Interventions

serum ostecalcin,serum sclerostin and parathroid profileDIAGNOSTIC_TEST

evaluation of bone turnover markers in blood

Eligibility

Sex: ALLMin age: 3 YearsMax age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * childern and adolsecents below 16 years of age diagnsed with type 1 diabetes for at least 1 year age and sex-matched control childern and adolsecents will be included Exclusion Criteria: * childern and adolescents with congenital bone disease, those with disorders of the parathyroid gland and those with chronic kidney disease.

Locations (1)

Sohag university Hospital

Sohag, Egypt

Outcomes

Primary Outcomes

level of serum ostecalcin, sclerostin in patients with type 1 diabetes ann d their age and sex matched control

markers of bone turnover in patients with type 1 diabetes and their matched control

Time frame: 12 months

Central Contacts

Hajar M Ismail, resident

CONTACT

01068447853 hagermoamen@med.sohag.edu.eg

Ahmed M Monir, assistant professor

CONTACT

Data from ClinicalTrials.gov

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