Exploring the Changes of Inflammatory Factors in Joint Fluid of Patients With Sports Injury for 1-year Postoperative Rehabilitation and Clinical Treatment

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University200 enrolled

Overview

This study intends to use a prospective study design method to continuously collect immune cell and inflammatory factor data of 5ml peripheral blood and 10ml joint fluid from 200 patients who met the inclusion and exclusion criteria in our department from January 2020 to January 2022. The aim is to analyze the impact of changes in inflammatory factors before and after surgery on postoperative recovery.

This study intends to use a retrospective study design method to continuously collect immune cell and inflammatory factor data of 5ml peripheral blood and 10ml joint fluid from 200 patients who met the inclusion and exclusion criteria in our department starting from January 2021. The aim is to analyze the impact of changes in inflammatory factors before and after surgery on postoperative recovery. The indicators of postoperative rehabilitation for patients were objectively evaluated using three scales: Lysholm scale, VAS scale, and Tegner scale. Among them, the Lysholm scale mainly evaluates the postoperative recovery of knee joint function in patients, with values ranging from 0 to 100. The higher the value, the better the recovery; The VAS scale mainly evaluates the postoperative pain score of patients, with values ranging from 0 to 10. The higher the value, the more severe the pain; The Tegner scale is also mainly used to evaluate the postoperative recovery of knee joint function in patients, with values ranging from 0 to 10. The higher the value, the better the recovery.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Anterior Cruciate Ligament Injuries

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Those with healthy diet and regular exercise habits; * Sports injury patients(Satisfy one of the following conditions): Anterior cruciate ligament injury or meniscus injury Exclusion Criteria: * Existence of underlying diseases related to the immune system; * Trauma leading to knee joint fracture; * Blood pressure, heart rate, vital capacity, muscle tension and other indicators are obviously abnormal; * Significant abnormalities in blood routine, infection indicators, heart, lung, liver, and kidney function tests, insufficient compensatory function of important organs, or severe systemic diseases; * Patients with neurological or psychiatric disorders, pregnant women, or a history of related illnesses combined with severe organic diseases

Outcomes

Primary Outcomes

Visual Analog Score for pain (VAS)

The VAS scale mainly evaluates the postoperative pain score of patients, with values ranging from 0 to 10. The higher the value, the more severe the pain;

Time frame: Change from 2 weeks, 1 month, 3 months, 6 months, and 1 Year after ACLR operation

Lysholm score

The Lysholm scale mainly evaluates the postoperative recovery of knee joint function in patients, with values ranging from 0 to 100. The higher the value, the better the recovery;

Time frame: Change from 6 months and 1 Year after ACLR operation

Tegner sacle

The Tegner scale is also mainly used to evaluate the postoperative recovery of knee joint function in patients, with values ranging from 0 to 10. The higher the value, the better the recovery