The current literature suggests that zinc supplementation may increase the duration of botulinum toxin; however, each study had their limitations. Further, no one has studied the effect of zinc supplementation for botulinum toxin treatment of the forehead. The purpose of this study is to evaluate the effect of zinc supplementation on frontalis muscle denervation by objectively assessing the degree of forehead rhytids and movement of the eyebrows.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
will take zinc citrate 4 days before and 1 week after botulinum toxin injection
will take placebo 4 days before and 1 week after botulinum toxin injection
Duration of botulinum toxin on eyebrow excursion
Measurement of eyebrow excursion
Time frame: 1 year
Duration of botulinum toxin effect on forehead rhytids
Visual assessment of return of forehead rhytids
Time frame: 1 year
Side effects of zinc administration
Monitor for adverse side effects of adjunct oral zinc therapy
Time frame: 1 year
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