The aim of the study is to determine the efficacy of the investigational product "Cream " : * on skin network after 56 days of daily application * on biological parameters linked to cellular communication involved in senescence * on sebum composition (metagenomics and metabolomics analysis)
This study will be conducted as a monocentric, randomized (for side of product application on forearms), open trial. 4 visits are planned: * Visit 1 - Inclusion (D1) * Visit 2 - Follow-up visit (D29), a window of +72 hours is allowed for this evaluation, * Visit 3 - End of the application period (D57), a window of +72 hours is allowed for this evaluation * Visit 4 - Follow-up visit (D7 post-biopsies +/- 24h) For a subject completing the study, the theoretical investigational product application will be 56 consecutive days up to 59 days maximum. The study duration for each subject will be 67 days maximum.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
33
* frequency of application: Once a day (in the morning) * modalities of application: Apply the cream on face (according to normal conditions of use) and on treated forearm, massage until complete penetration * area: The whole face, neck, neckline and one randomized forearm (external photo-exposed area) the other forearm is untreated * duration of investigational product application: 56 days (a window of + 72 hours is allowed) * quantity: 2 pressures of product for the whole face, neck and neckline and 1 pressure of product for the treated forearm
Spincontrol
Tours, France
Assessment of skin network (SRa parameter) by Fringe projection on silicone rubber replica (on one randomized forearm)
SRa: Average roughness (mm). Average variations in amplitude of the relief integrated into the studied surface.
Time frame: Change from baseline to Day 57
Assessment of skin network (SRq parameter) by Fringe projection on silicone rubber replica (on one randomized forearm)
SRq: Roughness with regards to the average quadratic plan (mm).
Time frame: Change from baseline to Day 57
Assessment of sebum metabolites' composition
Metabolomics analysis from sebum samples using mass spectrometry
Time frame: Change from baseline to Day 57
Assessment of skin metagenomic composition
Metagenomics analysis from sebum samples using targeted DNA sequencing
Time frame: Change from baseline to Day 57
Expression of cellular communication markers linked to senescence
RNA expression from skin biopsies using RNA-Seq
Time frame: Day 57
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.