The main objective is to determine if in-home portable air cleaners provide persistent reductions in PM2.5 exposures and improvements in systolic blood pressure and biochemical parameters over 4-weeks in patients with metabolic syndrome residing in Qatar.
Chronic cardio-metabolic diseases such as hypertension and diabetes contribute disproportionately to global morbidity and mortality and are increasing believed to have multiple environmental influences. PM2.5 is the fifth leading risk factor for global mortality - largely due to cardiovascular disease (CVD). Reducing personal exposure to air pollution has shown promise in improving key cardiovascular risk factors (blood pressure and insulin resistance) in limited studies, but durability of these effects is not known. Personal air cleaners have been shown to decrease personal exposure to PM2.5 and reduce blood pressure in small studies and may serve as a pragmatic intervention in high-risk patients in whom air pollution is a strong contributor to cardiovascular health.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
100
PM 2.5 exposure reduction using in home portable air cleaners fitted with HEPA filters
Simulation of PM 2.5 exposure reduction using in home portable air cleaners without HEPA filters.
Hamad Medical Corporation
Doha, Qatar
RECRUITINGChange in Systolic Blood Pressure
Mean change from baseline in systolic blood pressure
Time frame: week 4, week 10
Change in Fasting Glycemia
Mean change from baseline in fasting glycemia
Time frame: week 4, week 10
Change in Insulin Resistance Index
Mean change from baseline in Insulin Resistance Index
Time frame: week 4, week 10
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