Effects of Platelet-Rich Fibrin in Patients With Anterior Cruciate Ligament Reconstruction

Hacettepe University30 enrolled

Overview

The study was conducted to investigate the effects of platelet-rich fibrin on knee stability, knee muscle strength and knee function in patients with ACL reconstruction. Thirty patients with ACL reconstruction were included to the study and randomly divided into two groups. Patients were assessed preoperative and at the postoperative 1-year.

The study was conducted yo investigate the effects of platelet-rich fibrin (PRF) on the knee stability and function in patients with anterior cruciate ligament (ACL) reconstruction. Thirty patients with ACL reconstruction were included to the study and randomly divided into two groups (PRF group and control group). Hamstring tendon autograft was used in all patients for the reconstruction of the teared ACL. A standardized postoperative rehabilitation program was applied to all patients. Patients' knee stability, knee muscle strength and knee function were assessed preoperatively and one-year postoperatively. Knee stability was assessed using KT-2000 Knee Arthrometer. Quadriceps femoris and hamstring muscle strength measurements were conducted with an isokinetic dynamometer at 60˚/sec and 180˚/sec angular velocities. One Leg Hop (OLH) and Y-Balance tests, and International Knee Documentation Committee (IKDC) were used to evaluate the knee function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Effects of Platelet-Rich Fibrin on Knee Stability and Knee Function

Interventions

Platelet-Rich Fibrin during Standard ACL reconstruction surgeryBIOLOGICAL

Plateleth-rich fibrin was obtained from patients own blood (40 cc) and applied to the tunnels which were drilled for ACL graft

Standard ACL reconstruction surgeryOTHER

This was a control group where patients received Standard ACL reconstruction surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Being isolated ACL reconstruction, * Being between the ages of 18-45 years, * Performing sports recreationally or professionally Exclusion Criteria: * Having previous knee surgery, * Having systematic disease, * Having multiple ligament injury on the knee or additional cartilage injuries

Outcomes

Primary Outcomes

Changes in the Knee Laxity

Knee laxity was measured using Kneelax-3 Knee arthrometer

Time frame: Preoperatively ans one year postoperatively

Secondary Outcomes

Changes in the Knee Muscle Strenght

Qudriceps and hamstring muscle strength were measured using an isokinetic dynamometer

Time frame: Preoperatively ans one year postoperatively

Changes in the Knee Function

Knee function was assessed with one leg hop (OLH) test and Y-Balance tests

Time frame: Preoperatively and one year postoperatively

Data from ClinicalTrials.gov

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