The goal of this clinical trial is to explore whether preoperative stimulation of the distal limb of the ileostomy loop with gamma aminobutyric acid (GABA) could effectively reduce the incidence of complications after ileostomy closure. Participants will be divided into two groups. One group included patients treated with stimulation of the efferent loop with GABA prior to transit reconstruction surgery; the other control group was stimulated without giving any substance. Researchers will compare incidence of complications such as postoperative ileus, diarrhea and other parameters such as time to tolerating a diet, start of the passage of flatus, start of the passage of stool, postoperative stay, etc.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
80
Foley catheter No.14 Ch connected to an infusion set was introduced through the defunctioned bowel to allow the slow infusion, for 10-20 minutes, of a solution with 3000 mg of GABA diluted in 100 ml of 0.9% physiological saline.
Foley catheter No.14 Ch connected to an infusion set was introduced through the defunctioned bowel to allow the slow infusion, for 10-20 minutes, of 100 ml of 0.9% physiological saline.
incidence of complications after ileostomy closure
postoperative ileus, diarrhea, time to tolerating a diet, start of the passage of flatus, start of the passage of stool, postoperative stay.
Time frame: From date of randomization until the date of discharge, assessed up to 20 days
glucose metabolism-related parameters
Insulin, C peptide
Time frame: From date of randomization until the date of discharge, assessed up to 20 days
microbiota alteration
microbiota alteration before and after GABA stimulation
Time frame: From date of randomization until the date of discharge, assessed up to 20 days
metabolite alteration
metabolite alteration before and after GABA stimulation
Time frame: From date of randomization until the date of discharge, assessed up to 20 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.