This study is a randomized controlled trial to evaluate whether EEG-guided calibration of inhalation agents can reduce occurrence of EEG discontinuity in infants during general anesthesia.
This is a study for comparison of incidence of EEG discontinuity during general anesthesia using sevoflurane. EEG guidance group will receive calibration of fraction of inhalational sevoflurane according to components of slow wave and delta wave of raw EEG. Control group will receive conventional management of anesthesia according to vital signs.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
78
Monitoring of electroencephalogram via Sedline probe by MASIMO corporation. Adjust concentration of inhalational sevoflurane during anesthesia, according to component of slow\&delta wave and alpha wave, so that slow/delta oscillation (with or without alpha oscillation) is maintained.
Adjust concentration of inhalational sevoflurane during anesthesia, according to vital signs, so that mean blood pressure and heart rate are maintained between 80% and 120% of baseline values measured at ward before anesthesia.
Seoul National University Hospital
Seoul, Other, South Korea
EEG discontinuity
Incidence of EEG discontinuity (EEG amplitudes \< 25uV for more than 2 seconds)
Time frame: From start of anesthesia to end of anesthesia, Less than 24 hours
Total duration of EEG discontinuity
Total sum of duration of EEG discontinuity
Time frame: From start of anesthesia to end of study, Less than 24 hours
Significant isoelectric EEG
Incidence of significant isoelectric EEG (EEG amplitudes \< 10uV for more than 2 seconds)
Time frame: From start of anesthesia to end of study, Less than 24 hours
EtSev
Mean end-tidal sevoflurane concentration during anesthesia
Time frame: From start of anesthesia to end of study, Less than 24 hours
SEF
Mean spectral edge frequency value during anesthesia
Time frame: From start of anesthesia to end of study, Less than 24 hours
PSi
Mean patient state index value during anesthesia
Time frame: From start of anesthesia to end of study, Less than 24 hours
Mean blood pressure
Mean blood pressure values during anesthesia measured every 2.5 minutes
Time frame: From start of anesthesia to end of study, Less than 24 hours
Heart rate
Heart rate values during anesthesia measured every 2.5 minutes
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Time frame: From start of anesthesia to end of study, Less than 24 hours