A Pre-market Study to Evaluate b.Bone for Posterolateral Fusion (b.Spine Clinical Trial).

Inclusion Criteria: 1. Male or female patient ≥ 18 years old. 2. Patients requiring posterolateral fusion treatment for degenerative thoracolumbar, lumbar, or lumbosacral spinal conditions up to 8 levels. 3. Patients willing and able to attend the follow-up visits and procedures foreseen by the study protocol. 4. Patients who have provided written informed consent to participate in the study and the processing of personal data before any study procedure is performed. Exclusion Criteria: 1. Any previous surgical attempt(s) for spinal fusion (revision surgery) of the intended segment(s). 2. Patients who have been treated with chemotherapy or radiotherapy within 12 months before the enrolment. 3. Indication for spinal fusion because of an acute traumatic reason, like a spinal fracture. 4. Bone infection. 5. Bone malignant tumor(s). 6. Concomitant infectious systemic diseases, 7. Inflammatory systemic diseases, 8. Concomitant myeloproliferative disorders, 9. Active autoimmune disease, 10. Known or suspected allergy or hypersensitivity to the b.Bone device components, 11. Calcium metabolism disorder (i.e. hypercalcemia), 12. Known hyperthyroidism or autonomous thyroid adenoma. 13. Patients currently treated with systemic immunosuppressive agents. 14. Patients who are currently enrolled in another clinical study that would directly interfere with the current study, except when the patient is participating in a purely observational registry with no associated treatments. 15. Body mass index (BMI) larger than 36 (morbidly obese). 16. Known severe osteoporosis. 17. Patients requiring instrumented fusion in the cervical spine. 18. Woman who is pregnant or breast-feeding.