Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.

University of Catania44 enrolled

Overview

A randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with periodontitis. 44 patients with periodontitis treated with non surgical approach through Quadrant subgingival debridement or MINST. All the patients are assessed for clinical, periodontal, blood and non-invasive ultrasound cardiovascular parameters. Measurements are taken before and after initial periodontal treatment in the periodontal subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Atherosclerosis Periodontitis

Interventions

Non-surgical periodontal treatment by Q-SIPROCEDURE

Subgingival biofilm ultrasonic debridement

Non surgical periodontal debridement using MINST approachPROCEDURE

Non surgical periodontal treatment using MINST approach

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

PERIODONTITIS GROUP Inclusion Criteria: * Clinically diagnosed with periodontitis according to the EFP/AAP 2017 criteria. Exclusion Criteria: * Periodontal treatment, antibiotics, NSAIDs, immunosuppressants during the last 6 months. * Pregnancy. * Cardiovascular Diseases.

Locations (1)

AOU Policlinico G. Rodolico

Catania, Italy

Outcomes

Primary Outcomes

Flow-Mediated Dilation (FMD)

evaluation of Flow-Mediated Dilation changes in scale after treatment

Time frame: 6-months

Secondary Outcomes

Carotid Intima-Media Thickness (CIMT)

The thickness of the carotid intima and media changes in scale after treatment

Time frame: 6-months

Pulse Wave Velocity carotid-femoral (PWV-CR)

The speed of pulse wave propagation between carotid-radial sites changes in scale after treatment

Time frame: 6-months

Pulse Wave Velocity carotid-femoral (PWV-CF)

The speed of pulse wave propagation between carotid-femoral sites changes in scale after treatment

Time frame: 6-months

Advanced Glycation End products (AGEs)

AGES changes in scale after treatment. A group of endogenous heterogeneous compounds that are constantly formed under physiological conditions with prooxidant and cytotoxic properties. Measurements are performed by fluorescence spectroscopy technique.

Time frame: 6-months

Periodontal changes

Changes in probing depth, clinical attachment loss, bleeding sites

Time frame: 6 months

Advanced Glycation End products (AGEs)

A group of endogenous heterogeneous compounds that are constantly formed under physiological conditions with prooxidant and cytotoxic properties. Measurements are performed by fluorescence spectroscopy technique.

Time frame: 6-months

Data from ClinicalTrials.gov

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