Simultaneous radiotherapy followed by adjuvant immunotherapy is the standard treatment modality of unresectable stage III NSCLC. Our preliminary study confirmed that the treatment of CTV-omitted IMRT regimen did not compromise the PFS or OS and significantly reduced the incidence of severe radiation pneumonia and radiation esophagitis. The purpose of this study was to observe the role of radiotherapy modalities that omit CTV in the context of immunotherapy for NSCLC.
Study Type
OBSERVATIONAL
Enrollment
60
The enrollment was randomly (1:1) assigned into the study group with CTV-omitted IMRT and the control group with CTV-delineated IMRT using a random number table.
Progression-free survival
The time between randomization and the first occurrence of disease progression or die
Time frame: through study completion,up to 12 weeks
radiation respiratory events or esophagitis with grade 3 or higher
Time frame: after radiation therapy,up to 1 year
Overall survival
Time from randomization to death from any cause
Time frame: through study completion, an average of 2 year
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