Supplemental Hydrogen Plus PQQ for Mitochondrial Biomarkers and Brain Function in Elderly With Mild Cognitive Impairment

University of Novi Sad, Faculty of Sport and Physical Education34 enrolled

Overview

The goal of this randomized controlled double-blind parallel-group interventional trial is to evaluate the effects of dietary supplementation with molecular hydrogen and pyrroloquinoline quinone in elderly. The main questions it aims to answer are: (1) whether the supplementation affects biomarkers of mitochondrial function in serum, and (2) whether the supplementation affects cognition and brain metabolism. The participants will be subjected to take the dietary supplement during 6 weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Age-associated Memory Impairment

Interventions

Supplement

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 65 years * MMSE scores ranged from 23-27 * Informed consent signed Exclusion Criteria: * Take part in exercise on a regular basis * Severe chronic disease and acute injuries * History of dietary supplement use during the past 4weeks * No consent to randomization * Participation in other studies

Outcomes

Primary Outcomes

Fibroblast growth factor 21

Level of fibroblast growth factor 21 in serum

Time frame: Change from baseline serum fibroblast growth factor 21 at 6 weeks

Secondary Outcomes

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Level of peroxisome proliferator-activated receptor gamma coactivator 1-alpha 21 in serum

Time frame: Change from baseline serum peroxisome proliferator-activated receptor gamma coactivator 1-alpha at 6 weeks

Brain-derived neurotrophic factor

Level of brain-derived neurotrophic factor in serum

Time frame: Change from baseline serum brain-derived neurotrophic factor at 6 weeks

Irisin

Level of irisin in serum

Time frame: Change from baseline serum irisin at 6 weeks

General cognition

Mini-MentalStateExamination (MMSE) score

Time frame: Change from baseline MMSE score at 6 weeks

Brain creatine

MRS spectra for brain creatine

Time frame: Change from baseline brain creatine at 6 weeks

Brain oxygenation

Near-infrared spectroscopy for prefrontal oxygen saturation

Time frame: Change from baseline brain oxygenation at 6 weeks