Accelerated Recovery for Total Knee Replacement Surgery With Preoperative Intravenous Iron Combined With Human Erythropoietin for Rapid Hematopoietic Mobilization to Prevent Postoperative Anemia

Inclusion Criteria: * Age between 18 and 75 years (inclusive) and no gender restriction at the time of signing the informed consent form (ICF). * Patients who meet the diagnostic criteria for osteoarthritis according to the American College of Rheumatology (ACR) and are undergoing primary total knee arthroplasty due to end-stage osteoarthritis. Flexion deformity \<30°, varus deformity \<30°, valgus deformity \<20°. * Baseline hemoglobin level: 100g/L \< Hb \< 130g/L. * No deep venous thrombosis observed on preoperative bilateral lower limb venous color Doppler ultrasound. * The subject understands and voluntarily signs the written informed consent form (ICF) and is capable of complying with the scheduled visits and related procedures as outlined in the protocol. Exclusion Criteria: * Known allergy to any excipients in the investigational drugs iron sucrose and erythropoietin or a history of multiple allergies. * Mean corpuscular volume (MCV) \> 100 fL. * Numeric Rating Scale (NRS) score ≥ 3. * Presence of iron overload (serum ferritin \> 800 ng/ml) or iron utilization disorders (such as hemochromatosis and iron deposition disorders). * Blood disorders other than iron-deficiency anemia. * Blood transfusion within the past 30 days. * Use of iron preparations or HuEPO for the treatment of anemia within the past 30 days. * History of deep vein thrombosis or pulmonary embolism. * Patients with hypophosphatemia due to various causes. * BMI \< 18.5 kg/m2 or body weight \< 50 kg. * History of recent myocardial infarction, angina pectoris, cerebral infarction, or epileptic seizures within the past 6 months. * Use of medications affecting coagulation and antiplatelet function within the past week. * Moderate liver impairment: Decompensated liver cirrhosis or hepatitis, ALT, AST \> 3 times the upper limit of normal (ULN). * Moderate renal impairment: Serum creatinine (Cr) \> 150 µmol/L. * HIV or syphilis patients. * Pregnant or lactating women. * Participants who have previously participated in other clinical trials, provided the previous investigational drug exposure did not exceed 5 half-lives. * Acute infection, rheumatoid arthritis, or significant joint inflammation. * Patients deemed unsuitable to participate in this clinical trial by the investigator.