The main hypothesis of the HEPACORT study is that upon diagnosis of endogenous Cushing's syndrome, significant liver fibrosis may be present, particularly in the most severe forms of Cushing's syndrome. the HEPACORT study is the first exploratory study to assess the severity of liver fibrosis in patients with Cushing's syndrome or suspected of presenting by Magnetic Resonance Elastography (MRE).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
21
Magnetic Resonance Imaging (MRI) imaging with low-frequency vibrations to create a visual map (elastogram) that shows stiffness of body tissues
CHRU Nancy
Nancy, France
RECRUITINGEstimation of the severity of hepatic fibrosis by MRE (kPa).
Estimation of the severity of hepatic fibrosis in kPa by a non-invasive elastography method : magnetic resonance elastography.
Time frame: Baseline (day 0)
Evaluation of the presence of hepatic fibrosis by MRE (kPa).
Evaluation of the presence of hepatic fibrosis by ERM : ERM value ≥ 72.5 kPa.
Time frame: Baseline (day 0)
Evaluation of the association between hyperglycemia (blood glucose by g/L) with the presence of Fibrosis by MRE (kPa).
Time frame: Baseline (day 0)
Evaluation of the association between high blood pressure (mmHg) with the presence of Fibrosis by MRE (kPa).
Time frame: Baseline (day 0)
Evaluation of the association between overweight (kg) with the presence of Fibrosis by MRE (kPa).
Time frame: Baseline (day 0)
Evaluation of the association between osteoporosis (g/cm²) with the presence of Fibrosis by MRE (kPa).
Time frame: Baseline (day 0)
Evolution of transaminases (UI/L) between the diagnosis and the last visit.
Time frame: 1 year
Evolution of GGT (gamma-glutamyl transferase) (UI/L) between the diagnosis and the last visit.
Time frame: 1 year
Evolution of ALP (Alkaline Phosphatases) (UI/L) between the diagnosis and the last visit
Time frame: 1 year
Evolution of Bilirubin (mg/L) between the diagnosis and the last visit.
Time frame: 1 year
Evolution of Albumin (g/L) between the diagnosis and the last visit.
Time frame: 1 year
Evolution of platelets (platelets/mm3) between the diagnosis and the last visit.
Time frame: 1 year
Evolution of ferritin (ng/mL) between the diagnosis and the last visit.
Time frame: 1 year
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