Evaluation of several studies of the Clinic for Anesthesiology and Intensive Care Medicine CCM/CVK/CBF to create a register with the delirium data from anesthesiology study patients between 18 - 100 years. The primary purpose of the register is to assess factors influencing the development of delirium. In a subproject, risk factors that may lead to the development of postoperative delirium in the elderly will be evaluated with regard to gender differences using patients from the age of 60 with different surgical procedures. The risk factors examined are based on the evidence-based and consensus-based recommendations of the ESA guideline and literature review. In addition, the delirium incidence rate and the delirium severity is examined regarding gender differences.
Study Type
OBSERVATIONAL
Enrollment
5,000
Department of Anaesthesiolgy and Intensive Care Medicine CVK/CCM, Charité - Univeristy Medicine Berlin
Berlin, Germany
Delirium
Validated delirium scoring (points, duration and severity)
Time frame: Up to 5 years
Sedation scales
Sedation is measured by the Richmond Agitation Sedation Scale
Time frame: Up to 5 years
Socioeconomic information 1
Soci-economic information is collected by FIMA
Time frame: Up to 5 years
Socioeconomic information 2
Soci-economic information is collected by the Nikolaus-score (social situation), 1. Subscale
Time frame: Up to 5 years
Socioeconomic information 3
Soci-economic information is collected by items on socioeconomic status from the Federal Health Survey of 1998
Time frame: Up to 5 years
Comorbidities
Comorbidities are new diagnoses from hospital records.
Time frame: Up to 5 years
Charlson comorbidity index
Comorbidity scores
Time frame: Up to 5 years
Lifestyle risks 1
Consumption of alcohol is measured by AUDIT (Alcohol Use Disorders Identification Tests)
Time frame: Up to 5 years
Lifestyle risks 2
Consumption of and nicotine is measured by Fagerström Test for Cigarette Dependence (FTCD). Questionnaire scored 0-10 points with Total Score equal to the sum of all points
Time frame: Up to 5 years
Lifestyle risks 3
Consumption of nicotine is measured by Smocking Pack Years (SPY)
Time frame: Up to 5 years
Lifestyle risks 4
Previous consumption of nicotine is measured by History of Smoking.
Time frame: Up to 5 years
Level of education
Level of education is measured by ISCED (International Standard Classification of Education)
Time frame: Up to 5 years
Quality of life - relatives
Quality of life is measured by CarerQoL
Time frame: Up to 5 years
Quality of life - self 1
Quality of life is measured by EQ-5D.An index calculated from the five EQ-5D (3L and 5L) dimensions by attaching specific weights to each severity level in each dimension.
Time frame: Up to 5 years
Quality of life - self 2
Quality of life is measured by WHO-5. WHO-5 is a short and generic global rating scale measuring subjective well-being, the respondent is asked to rate how well each of the 5 statements applies to him or her when considering the last 14 days. Each of the 5 items is scored from 5 (all of the time) to 0 (none of the time). The raw score ranges from 0 (absence of well-being) to 25 (maximal well-being). Scores are then converted to a percentage scale from 0 (absent) to 100 (maximal). Higher scores represent greater psychological well-being.
Time frame: Up to 5 years
Quality of life - self 3
Quality of life is measured by SF-12 (Short form health survey)
Time frame: Up to 5 years
Functional impairment (IADL) 1
Instrumental Activities of Daily Living (IADLs) \< 8
Time frame: Up to 5 years
Functional impairment (ADL) 2
Activities of Daily Living (ADLs) \< 100
Time frame: Up to 5 years
Depression 1
Depression 1 is measured by PHQ-8 (Patient Health Questionnaire depression scale)
Time frame: Up to 5 years
Depression 2
Depression 2 is measured by GDS (Geriatric Depression Scale)
Time frame: Up to 5 years
Depression 3
Depression 3 is measured by HADS (Hospital Anxiety and Depression Scale)
Time frame: Up to 5 years
Depression 4
Depression 4 is measured by CDS (Cornel Depression Scale)
Time frame: Up to 5 years
Anxiety scales 1
Anxiety is measured by GAD-7 (Generalized Anxiety Disorder 7)
Time frame: Up to 5 years
Anxiety scale 2
Anxiety 2 is measured by FAS (Faces Anxiety Scale)
Time frame: Up to 5 years
Anxiety scale 2
Anxiety 2 is measured by GAD-7
Time frame: Up to 5 years
Pain
Pain is measured by numeric pain scales (minimum = 0, maximum = 10).
Time frame: Up to 5 years
Type of concomitant medication
The medication administered during the hospital stay is documented.
Time frame: Up to 5 years
Anticholinergic Load
Measured by anticholinergic drug scale
Time frame: Up to 5 years
Frailty
Frailty is measured with a modified frailty score according to Fried´s frailty phenotype assessment.
Time frame: Up to 5 years
Nutritional status 1
Nutritional status 1 is measured by calf circumference
Time frame: Up to 5 years
Nutritional status 2
Nutritional status 2 is measured by arm circumference
Time frame: Up to 5 years
Nutritional status 3
Nutritional status 3 is measured by changes in weight
Time frame: Up to 5 years
Nutritional status 4
Nutritional status 4 is measured by changes in body mass index
Time frame: Up to 5 years
Nutritional status 5
Nutritional status 5 is measured by previous weight history (3 months)
Time frame: Up to 5 years
Nutritional status 6
Nutritional status 6 is measured by Medi-Score
Time frame: Up to 5 years
Nutritional status 7
Nutritional status 7 is measured by MNA-SF
Time frame: Up to 5 years
Nutritional status 8
Nutritional status 8 is measured by Sarcopenia
Time frame: Up to 5 years
Nutritional status 9
Nutritional status 9 is measured by Nutritional Risk Screening (NRS 2002)
Time frame: Up to 5 years
Nutritional status 10
Nutritional status 10 is measured by AKE Screening
Time frame: Up to 5 years
Mobility 1
Mobility 1 is measured with the Timed up and Go
Time frame: Up to 5 years
Mobility 2
Mobility 2 is measured with a walking test: Slowness: Calculated after walking 3 meters, adjusted for sex and height, according to Fried. The cut-off points for 3 meters were established as, in men: height ≤173 cm and time ≥4.59 s (equivalent to 0.65 m/s); height \>1.73 cm and time ≥3.93 s (equivalent to 0.76 m/s); and for women: height ≤1.59 cm and time ≥4.59 s (0.65 m/s); and height \>1.59 cm and time ≥3.93 s (0.76 m/s).
Time frame: Up to 5 years
Number of participants with changes in laboratory values 1
Laboratory results in the hospital including hemoglobin, lymphocytes, total neutrophils, platelet count, white blood cell (WBC) count and inflammatory markers from blood samples.
Time frame: Up to 5 years
Number of participants with changes in laboratory values 2
Laboratory results in the hospital from serum samples
Time frame: Up to 5 years
Number of participants with changes in laboratory values 3
Laboratory results in the hospital from urine samples
Time frame: Up to 5 years
Number of participants with changes in laboratory values 4
Laboratory results in the hospital from liquor samples
Time frame: Up to 5 years
Depth of sedation
The sedation was measured intraoperatively processed electroencephalogram (EEG) Full-brain EEG recording with surface electrodes, raw EEG analysis measured during the operation.
Time frame: Up to 5 years
Type of operation
Type of operation is measured by OPS-Code
Time frame: Up to 5 years
Duration of operation
Type of operation is measured in minutes
Time frame: Up to 5 years
Type of anesthesia
There are four main categories of anesthesia used during surgery and other procedures: general anesthesia, regional anesthesia, sedation (sometimes called "monitored anesthesia care"), and local anesthesia.
Time frame: Up to 5 years
Duration of anesthesia
Duration of anesthesia is measured in minutes.
Time frame: Up to 5 years
Length of hospital stay
Hospital stay is measured in days.
Time frame: Up to 5 years
Intensive care unit stay
Intensive care unit stay is measured in hours.
Time frame: Up to 5 years
Organ complications
Organ complications are recorded in hospital records
Time frame: Up to 5 years
Hospital discharge criteria
Discharge criteria are measured at hospital discharge by Post Anesthetic Discharge Scoring System (PADS) Score
Time frame: Up to 5 years
Mortality
Mortality rate is measured after 1,2,3,4 and 5 years
Time frame: Up to 5 years
Study data
Identification of study data with a high impact on delirium from the study databases
Time frame: Up to 5 years
Sleeping items
Questions measuring personal satisfaction with sleep quality and duration As measured by questions measuring personal satisfaction with sleep quality and duration
Time frame: Up to 5 years
Circadian rhythm variables
Items measuring circadian rhythm variables e.g. Zeitgebers
Time frame: Up to 5 years
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