Short Integrative And Neurocognitive Therapy For Young Adults With Borderline Personality Disorder

Centre Hospitalier Universitaire de Nīmes74 enrolled

Overview

Borderline personality disorder (BPD) is a severe, high-suicidal psychiatric disorder associated with impulsive, endangering behaviors. Young patients between 16 and 25 years old do not respond to traditional psychotherapies, which are often long and not adapted to their neurocognitive alterations linked to early trauma. The study authors hypothesize the SINTYA therapy program (one group session and one individual session weekly for 10 weeks) would reduce the level of impulsivity and clinical symptomatology (severity of the BPD; emotional regulation difficulties; dissociative symptoms; aggressiveness; ruminations; the number of self-destructive behaviors and suicidal acts; impulsive behaviors; level of suicide risk and hopelessness; the number of psychiatric hospitalizations and emergency visits for psychiatric reasons; and finally improving psychosocial functioning).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Borderline Personality Disorder

Interventions

Eligibility

Sex: ALLMin age: 16 YearsMax age: 25 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of BPD according to DSM-5 criteria and BPQ-80 scale. * High BPD severity level: ZAN-BPD (score ≥ 18/36). * Understand, write and read French. * Be able to understand the nature, purpose and methodology of the study and agree to cooperate during evaluations. * Have signed the informed consent. * For minor patients, have signed the parental consent by at least one holder of parental authority. Exclusion Criteria: * Refusal to participate. * Existence of a neurological pathology or cerebral sequelae of organic origin which could affect neurocognitive performance. * Intelligence quotient \< 70. * Lifetime diagnosis of schizoaffective disorder or schizophrenia (MINI-7). * Previous or current participation in specific psychotherapy for BPD. * Subject deprived of liberty (by judicial or administrative decision) and/or protected by law. * Inclusion in another study including psychotherapy for the duration of the study. * Inclusion in a drug RIPH1 study or in a REC study (European regulation of clinical trials) for the entire duration of the study. * Subject in period of exclusion from another research protocol.

Outcomes

Primary Outcomes

Variation in explicit impulsivity between groups

UPPS-S (Impulsive Behavior Scale Short version score)

Time frame: Baseline

Variation in explicit impulsivity between groups

UPPS-S (Impulsive Behavior Scale Short version score)

Time frame: Month 4

Secondary Outcomes

Variation in explicit impulsivity between groups

UPPS-S (Impulsive Behavior Scale Short version score)

Time frame: Month 7

Variation in impulsiveness between groups

Barratt Impulsiveness Scale (BIS-11) (score out of 120)

Time frame: Baseline

Variation in impulsiveness between groups

Barratt Impulsiveness Scale (BIS-11) (score out of 120)

Time frame: Month 4

Variation in impulsiveness between groups

Barratt Impulsiveness Scale (BIS-11) (score out of 120)

Time frame: Month 7

BPD severity level between groups

Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) (score out of 36)

Time frame: Baseline

BPD severity level between groups

Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) (score out of 36)

Time frame: Month 4

BPD severity level between groups

Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) (score out of 36)

Time frame: Month 7

Emotional regulation capacities between groups

Difficulties in Emotion Regulation Scale (DERS-18)

Time frame: Baseline

Emotional regulation capacities between groups

Difficulties in Emotion Regulation Scale (DERS-18)

Time frame: Month 4

Emotional regulation capacities between groups

Difficulties in Emotion Regulation Scale (DERS-18)

Time frame: Month 7

Dissociative symptoms between groups

Dissociative Experiences Scale (DES): a score of 25 or higher is predictive of dissociative disorder

Time frame: Baseline

Dissociative symptoms between groups

Dissociative Experiences Scale (DES): a score of 25 or higher is predictive of dissociative disorder

Time frame: Month 4

Dissociative symptoms between groups

Dissociative Experiences Scale (DES): a score of 25 or higher is predictive of dissociative disorder

Time frame: Month 7

Aggression between groups

Aggression Questionnaire (AQ-12)

Time frame: Baseline

Aggression between groups

Aggression Questionnaire (AQ-12)

Time frame: Month 4

Aggression between groups

Aggression Questionnaire (AQ-12)

Time frame: Month 7

Ruminations between groups

Rumination Reflection Questionnaire (RRQ)

Time frame: Baseline

Ruminations between groups

Rumination Reflection Questionnaire (RRQ)

Time frame: Month 4

Ruminations between groups

Rumination Reflection Questionnaire (RRQ)

Time frame: Month 7

Number of self-destructive behaviors between groups

Number of self-destructive/self-mutilatory/parasuicidal acts reported by the patient in a clinical interview

Time frame: Baseline

Number of self-destructive behaviors between groups

Number of self-destructive/self-mutilatory/parasuicidal acts reported by the patient in a clinical interview

Time frame: Month 4

Number of self-destructive behaviors between groups

Number of self-destructive/self-mutilatory/parasuicidal acts reported by the patient in a clinical interview

Time frame: Month 7

Number of impulsive behaviors between groups

Number of impulsive behaviors (food, motor vehicles, sexual, drug-related)

Time frame: Baseline

Number of impulsive behaviors between groups

Number of impulsive behaviors (food, motor vehicles, sexual, drug-related)

Time frame: Month 4

Number of impulsive behaviors between groups

Number of impulsive behaviors (food, motor vehicles, sexual, drug-related)

Time frame: Month 7

Level of suicide risk between groups

Columbia-Suicide Severity Rating Scale (C-SSRS)

Time frame: Baseline

Level of suicide risk between groups

Columbia-Suicide Severity Rating Scale (C-SSRS)

Time frame: Month 4

Level of suicide risk between groups

Columbia-Suicide Severity Rating Scale (C-SSRS)

Time frame: Month 7

Number of psychiatric hospitalizations and emergency visits for psychiatric reasons between groups

Information taken from patient medical file

Time frame: 12 Months prior to inclusion

Number of psychiatric hospitalizations and emergency visits for psychiatric reasons between groups

Information taken from patient medical file

Time frame: Baseline

Number of psychiatric hospitalizations and emergency visits for psychiatric reasons between groups

Information taken from patient medical file

Time frame: Month 4

Number of psychiatric hospitalizations and emergency visits for psychiatric reasons between groups

Information taken from patient medical file

Time frame: Month 7

Psychosocial functioning between groups

Functional Assessment Staging Tool (FAST)

Time frame: Baseline

Psychosocial functioning between groups

Functional Assessment Staging Tool (FAST)

Time frame: Month 4

Psychosocial functioning between groups

Functional Assessment Staging Tool (FAST)

Time frame: Month 7

Implicit impulsivity between groups

Continuous Performance Test (CPT)

Time frame: Baseline

Implicit impulsivity between groups

Continuous Performance Test (CPT)

Time frame: Month 4

Implicit impulsivity between groups

Continuous Performance Test (CPT)

Time frame: Month 7

Neurocognitive evaluation of implicit impulsivity between groups

Emotional Stroop (SE) customized to the study

Time frame: Baseline

Neurocognitive evaluation of implicit impulsivity between groups

Emotional Stroop (SE) customized to the study

Time frame: Month 4

Neurocognitive evaluation of implicit impulsivity between groups

Emotional Stroop (SE) customized to the study

Time frame: Month 7

Risk taking between groups

Balloon Analogue Risk Task (BART)

Time frame: Baseline

Risk taking between groups

Balloon Analogue Risk Task (BART)

Time frame: Month 4

Risk taking between groups

Balloon Analogue Risk Task (BART)

Time frame: Month 7

Decision making under risk conditions between groups

Game Dice Task (GDT)

Time frame: Baseline

Decision making under risk conditions between groups

Game Dice Task (GDT)

Time frame: Month 4

Decision making under risk conditions between groups

Game Dice Task (GDT)

Time frame: Month 7

Short Integrative And Neurocognitive Therapy For Young Adults With Borderline Personality Disorder

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts