This study aimed to aim to investigate the efficacy of individualized rTMS according to lateralization index on motor recovery and cortical excitability in subacute stroke patients.
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technology. High and low frequencies of rTMS could modulate the excitability of the cerebral cortex. Theta burst stimulation (TBS) has achieved a similar effect to traditional rTMS mode. However, the current rTMS studies for stroke patients utilized the same therapeutic protocol and there is no individualized rTMS protocol based on the value of lateralization index. This study aimed to aim to investigate the efficacy of individualized rTMS according to lateralization index on motor recovery and cortical excitability in subacute stroke patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technology. High and low frequencies of rTMS could modulate the excitability of the cerebral cortex.
National Taiwan University Hospital
Taipei County, Taipei, Taiwan
RECRUITINGFugl-Meyer Assessment
Fugl-Meyer Assessment motor function set, score: 0-66, higher scores indicate a better outcome.
Time frame: 12 weeks post intervention
Medical Research Council (MRC) Scale for Muscle Strength
Medical Research Council (MRC) Scale for Muscle Strength, assessing muscle strength from Grade 5 (normal) to Grade 0 (no visible contraction).
Time frame: 1 week, 4 weeks, 12 weeks post intervention
National Institutes of Health Stroke Scale
National Institutes of Health Stroke Scale, The maximum possible score is 42, with the minimum score being a 0. Higher scores indicate a worse outcome.
Time frame: 1 week, 4 weeks, 12 weeks post intervention
Barthel Index
Barthel Index, score 100-0. Higher scores indicate a better outcome.
Time frame: 1 week, 4 weeks, 12 weeks post intervention
Modified Rankin Scale
Modified Rankin Scale, score from 0 to 6. Higher scores indicate a worse outcome.
Time frame: 1 week, 4 weeks, 12 weeks post intervention
MEP
motor evoked potential
Time frame: 1 week, 4 weeks, 12 weeks post intervention
Fugl-Meyer Assessment
Fugl-Meyer Assessment motor function set, score: 0-66, higher scores indicate a better outcome.
Time frame: 1 week, 4 weeks post intervention
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functional NIRS
Functional Near Infrared Spectroscopy to detect the cortical excitability
Time frame: 1 week, 4 weeks, 12 weeks post intervention