Among adults, patients undergoing elective extracorporeal circulation for cardiac surgery are included in the ERAS strategy intervention plan, which mainly includes preoperative education, preoperative oral intake of multidimensional carbohydrate beverages, multimodal analgesia, blood protection strategies, correction of perioperative hypoalbuminemia, early removal of tracheal intubation, maintenance of blood sugar at reasonable levels, and targeted liquid therapy. The traditional plan group follows the current clinical diagnosis and treatment routine. By comparing the differences in the incidence of major postoperative outcomes (MACCE events, major pulmonary complications, and acute kidney injury) between the intervention group and the non intervention group, as well as comparing other adverse events (including but not limited to pneumonia, massive bleeding, postoperative arrhythmia, incision infection, postoperative nausea, vomiting, and delirium), all cause secondary intubation, and all cause secondary surgery between the two groups, and recording hospitalization time, ICU stay time The removal time of tracheal intubation and drainage tube, as well as the pain score during hospitalization and the total amount of opioid drug use (converted to equivalent dose morphine), hospitalization cost, postoperative recovery quality QoR15 scale score, and patient satisfaction score, were recorded to explore whether the ERAS regimen can reduce the incidence of major postoperative adverse events, improve patient prognosis, and accelerate postoperative recovery compared to traditional regimens.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
3,600
Among adults, patients undergoing elective extracorporeal circulation for cardiac surgery are included in the ERAS strategy intervention plan, which mainly includes preoperative education, preoperative oral intake of multidimensional carbohydrate beverages, multimodal analgesia, blood protection strategies, correction of perioperative hypoalbuminemia, early removal of tracheal intubation, maintenance of blood sugar at reasonable levels, and targeted liquid therapy.
Fuwai hospital
China, Beijing Municipality, China
Fuwai hospital
China, Beijing Municipality, China
Composite outcomes
The composite outcomes include the major adverse cardiac and cerebrovascular events (MACCE), major postoperative pulmonary complication (PPCs), and acute kidney injury (AKI).
Time frame: during hospitalization, an average of 1 week, assessed up to 30 days
the quality of recovery score (QoR)-15 after surgery
Time frame: At 24 hour after surgery
length of hospital stay
From the date of admission until the date of discharging
Time frame: From the date of admission until the date of discharging, assessed up to 30 days
the duration of intensive care unit (ICU) stay
Time from ICU admission to ICU discharge
Time frame: Time from ICU admission to ICU discharge, assessed up to 30 days
time to extubation
The time from the end of operation to the removal of tracheal intubation
Time frame: The time from the end of operation to the removal of tracheal intubation, assessed up to 30 days
time to drainage removal
The time from the end of operation to the removal of drainage tube
Time frame: The time from the end of operation to the removal of drainage tube, assessed up to 30 days
the rate of other complications
The rate of other complications include delium, pneumonia, pneumothorax, hematorrhea and so on
Time frame: during hospitalization, an average of 1 week, assessed up to 30 days
the rate of reintubation for any cause
The rate of reintubation for any cause
Time frame: during hospitalization, an average of 1 week, assessed up to 30 days
cumulative opioid dosage
Total perioperative consumption of opioid analgesics
Time frame: during hospitalization, an average of 1 week, assessed up to 30 days
overall medical costs
Total cost of patients during hospitalization
Time frame: during hospitalization, an average of 1 week, assessed up to 30 days
satisfaction score
A satisfaction rating using a 0-10 number scale (0=unsatisfactory, 10=satisfactory)
Time frame: the day before discharge, assessed up to 30 days
the outcomes of long-term prognosis by telephone follow-up
the outcomes of prognosis
Time frame: within 30 days, 3 months, and 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.