Evaluation of Intestinal Microbiota Implication in Ruptured Intracranial Aneurysm

N/ANot Yet RecruitingNCT05914636

Hospices Civils de Lyon50 enrolled

Overview

The physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. The microbiota is known to interact with brain and can promote inflammation. The objective of this study is to describe microbiota with taxonomic and metabolomic analysis. A comparison between ruptured and unruptured intracranial aneurysm will be performed. The study hypothesis is that microbiota is different between ruptured and unruptured patient.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intracranial Sacciform Aneurysm

Interventions

analysis of foecal microbiotaBIOLOGICAL

An analysis of foecal microbiota including taxonomic and metabolomic analysis will be performed and compared between ruptured and unruptured patient. confundens factors as diet, obesity for microbiota and as smoking, hypertension, size for aneurysm ruptured will be sampled and independence will be analyzed.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * one or more intracranial sacciform aneurysm ruptured or not in function of the inclusion group Exclusion Criteria: * Transient modification of microbiota: Antibiotherapy in the last 3 months, pre or probiotic in the last month, gastrostomy, ileostomy, bariatric surgery, digestive tract resection, gastro-duodenal ulcer surgery or during the last month, chronic inflammatory disease of the digestive tract (like Crohn), BMI for more than 30, Very restrictive diet (like vegan * Specific pathologies increasing the incidence of aneurysm ( kidney autosomic dominant polycystosis, Type 1 neurofibromatosis, Rendu-Osler, MArfan * Participation to a study with the objective of microbiota modification

Outcomes

Primary Outcomes

Taxonomic faecal microbiota description

The results of the taxonomic analysis of fecal samples will be described in the two groups. Interesting parameter will be selected for further analysis

Time frame: The faecal samples will be taken at 3 days+/-2 after the ruptured and during the arteriography for the unruptured group within 3 months after inclusion

Central Contacts

Dumot Chloé, Dr PhD

CONTACT

+334 72355839 chloe.dumot@chu-lyon.fr

Data from ClinicalTrials.gov

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