Older patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT) often die from other causes than lung cancer due to age-related comorbidities. This national randomized study will include 130 patients throughout 5 Danish cancer centres and investigate if a comprehensive geriatric intervention (CGA) when added upfront to SBRT for patients with localized NSCLC will have an impact on quality of life (QoL), overall survival, physical functionality and unplanned hospital admissions. If an upfront CGA improves patients' general health status, this study could lead to implementation of a CGA in standard clinical practice as well as further research on older patients receiving radiotherapy.
Study Type
OBSERVATIONAL
Enrollment
130
Comprehensive geriatric assessment (CGA) is defined as a multidisciplinary diagnostic and treatment process that identifies medical, psychosocial, and functional capabilities of an older adult in order to develop a coordinated plan to maximize overall health with aging.
Aarhus University Hospital
Aarhus, Aarhus N, Denmark
RECRUITINGRigshospitalet
Copenhagen, Denmark
RECRUITINGOdense University Hospital
Odense, Denmark
RECRUITINGVejle Hospital
Vejle, Denmark
RECRUITINGQuality of Life (EQ-5D)
Questionnaire with 5 dimensions each with 5 (1-5) levels representing the health status of the patient and the patients self-rated health status on a scale from 0-100 (EQ VAS). The score of the 5 dimensions can be converted into a single index value 0-1 with higher values indicating poorer health status.
Time frame: 12 months
Overall Survival (OS)
The time from treatment to death, regardless of disease recurrence
Time frame: 12 months
Quality of Life (EQ-5D)
Questionnaire with 5 dimensions each with 5 (1-5) levels representing the health status of the patient and the patients self-rated health status on a scale from 0-100 (EQ VAS). The score of the 5 dimensions can be converted into a single index value 0-1 with higher values indicating poorer health status.
Time frame: 3 months
Quality of Life (EQ-5D)
Questionnaire with 5 dimensions each with 5 (1-5) levels representing the health status of the patient and the patients self-rated health status on a scale from 0-100 (EQ VAS). The score of the 5 dimensions can be converted into a single index value 0-1 with higher values indicating poorer health status.
Time frame: 6 months
Quality of Life (EQ-5D)
Questionnaire with 5 dimensions each with 5 (1-5) levels representing the health status of the patient and the patients self-rated health status on a scale from 0-100 (EQ VAS). The score of the 5 dimensions can be converted into a single index value 0-1 with higher values indicating poorer health status.
Time frame: 9 months
Hand-grip strength
Hand-grip strength measured in kilo using a JAMAR hand dynamometer
Time frame: 12 months
Timed-up-and-go (TUG)
TUG consists of timing (seconds) a patient getting up from a chair from the sitting to the bipedal position, walking three meters, turning, returning, and sitting on the chair again
Time frame: 12 months
Chair-stand-test (CST)
The CST involves recording the number of "stands" from a chair a person can complete in 30 seconds
Time frame: 12 months
Unplanned Admissions
Time to first unplanned admission
Time frame: 12 months
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