The purpose of this study is to evaluates how probiotics and dietary supplementation with an herbal powder can shift the gut microbiome in those with non-cystic acne vulgaris.
The investigators hope to evaluate the effects of oral supplements in changing intestinal health and the gut bacteria in patients with non-cystic acne vulgaris. Acne is a chronic inflammatory condition that is estimated to affect greater than 85% of the population at some point. While antibiotics are typically used for systemic therapy, it can increase the risk for drug-resistant bacteria and shift the gut microbiome in a negative way. On the other hand, probiotics and dietary supplementation have been shown to support the gut microbiome. In this study, participants will be randomized to either receiving a probiotic or powder supplement. This means that participants will have an equal chance of receiving either product as half of the participants will be randomized to receive only oral probiotic, and the other half will receive oral supplement powder.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
36
Oral probiotic
oral herbal powder
Integrative Skin Science and Research
Sacramento, California, United States
Gut microbiome composition of short chain fatty acid producing bacteria
Change on the relative abundance of Akkermansia mucinaphila and Facelibacterium pruasntizii
Time frame: 8 weeks
Stool acetate levels
Assess the short chain fatty acid stool acetate levels
Time frame: 8 weeks
Change in salivary progesterone levels
Progesterone and 17-OH progesterone levels
Time frame: 4 weeks
Change in salivary progesterone levels
Progesterone and 17-OH progesterone levels
Time frame: 8 weeks
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