This is a randomized control, double-blind study in which women who are about to go an elective vaginal hysterectomy are offered to participate. Patients will be randomly assigned to one of two groups: the tranexamic acid group, in which 1 gram of tranexamic acid (Hexakapron) is administered intravenously before surgery, and the control group, in which patients will receive 10 ml of normal saline 0.9% intravenously.
This is a randomized control, double-blind study in which women who are about to go for an elective vaginal hysterectomy are offered to participate. Patients will be randomly assigned to one of two groups: the tranexamic acid group, in which 1 gram of tranexamic acid (Hexakapron) is administered intravenously before surgery, and the control group, in which patients will receive 10 ml of normal saline 0.9% intravenously. A nurse will prepare the solution according to the randomization and will handle it to the anesthesiologist.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
80
One gram of tranexamic acid (Hexakapron) is administered intravenously before surgery
patients will receive 10 ml of normal saline 0.9% intravenously.
Wolfson medical center
Holon, Israel
RECRUITINGMean objective assessment of blood loss
Objective assessment of blood loss is calculated by subtraction the weight of used pads after the surgery from the preoperative weight (blood lost during surgery will be absorbed by pads only, without using suction); 1 g of absorbed fluid will be converted to 1 mL of blood.
Time frame: Immediately after surgery
Mean subjective blood loss (SBL)
SBL will be estimated by the senior surgeon.
Time frame: Immediately after surgery
Mean difference in hemoglobin levels before and after surgery
Preoperative and postoperative hemoglobin level difference
Time frame: One day after surgery
The number of patients who need blood products transfusion
The need of blood transfusion or other blood products in order to treat excessive blood loss
Time frame: 30 days after surgery
The size of pelvic hematoma after surgery
Postoperative pelvic hematoma, diagnosed and measured by ultrasound
Time frame: One day after surgery
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