The goal of this clinical trial is to compare the effect of high chlorine solution such as normal saline and non-high chlorine solution such as sodium lactate ringer's solution on renal function in patients with heat stroke. The main question it aims to answer is whether limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke. Participants will receive a free normal saline infusion during the emergency department according to the study design, or a restricted normal saline infusion while using sodium lactate Ringer's instead. Researchers will compare the normal saline infusion group and sodium lactate Ringer's group to see if limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
190
The heat stroke patients will be infused with different chlorine concentrations fluid during the emergency department.
YongKang First People's Hospital
Guli, Zhejiang, China
RECRUITINGYiwu Central Hospital
Yiwu, Zhejiang, China
RECRUITINGDongyang People's Hospital
Dongyang, China
RECRUITINGThe Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
RECRUITINGJinhua Municipal Central Hospital
Jinhua, China
RECRUITINGJinhua People's Hospital
Jinhua, China
RECRUITINGLanxi People's Hospital
Lanxi, China
RECRUITINGAcute kidney injury
Acute kidney injury was defined as increase in serum creatinine by 50% within 7 days, or increase in serum creatinine by 0.3 mg/dl (26.5μmol/l) within 2 days, or oliguria
Time frame: up to 90 days
Continuous renal replacement therapy
number of participants need continuous renal replacement therapy
Time frame: up to 90 days
length of ICU stay
The length patient stay in ICU
Time frame: up to 90 days
in-hospital mortality
number of participants dead in hospital
Time frame: up to 90 days
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