Application of High-flow Nasal Oxygen in Cesarean Section

N/ACompletedNCT05921955

Beijing Tongren Hospital120 enrolled

Overview

The study propose that the using the high-flow nasl oxygen to provide oxygen for maternal can improve the fetal acidemia and the neonatal outcomes during cesarean section with combined spinal-epidural anesthesia.

Maternal oxygen supplementation is widely used intrauterine resuscitation technique in clinical, which can improve fetal oxygenation and prevent fetal acidemia. The incidence of hypotension is high in cesarean section with combined spinal-epidural anesthesia. Hypotension contributes to insufficient perfusion of uterus and placenta, resulting in decreased fetal oxygen supply and neonatal acidemia. High flow nasal oxygen have a better improvement oxygenation of patients by providing high flow oxygen airflow with heating and humidification through nasal cannula.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

120

Conditions

Fetal Acidemia

Interventions

Optiflow high-flow nasal cannula systemDEVICE

Using the Optiflow high-flow nasal cannula system to supply oxygen for maternal.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * An elective cesarean section in Beijing Tongren Hospital * ≥37 weeks' gestation * American society of Aneshesiologists（ASA） I-III * Aged 18 to 45 years old * The fasting time is 6-8h, and the water restriction time is ≥2h * Anesthesia: combined spinal-epidural anesthesia * Agree to the study and sign the informed consent Exclusion Criteria: * Fetal or placental abnormalities are known * Maternal has complications * Maternal BMI ≥40 kg/m2 * History of difficult intubation or known difficult airway * Contraindications for HFNO such as nasal lesions or structural changes * Gastric reflux disease

Locations (1)

Beijing tongren Hospital, Capital Medical University

Beijing, Beijing Municipality, China