This study assesses the impact of tezepelumab treatment not only on asthma control but also on cough specific Health-Related Quality of Life (HRQoL). Asthma control can be evaluated using Asthma Control Questionnaire (ACQ). Cough symptom which is one of the symptoms related airway hyperresponsiveness can be assessed via the relevant questionnaire, Leicester Cough Questionnaire (LCQ). There is moderate negative correlation between ACQ and LCQ . Improvements in both asthma control and cough symptom by tezepelumab would clarify effectiveness of Tezepelumab in real-world. Though Tezepelumab is recently approved in Japan, there is no real-world evidence on tezepelumab, particularly on above mentioned symptoms. Thus, this study aims to estimate effectiveness of tezepelumab on asthma and cough symptoms in real world settings.
Study Type
OBSERVATIONAL
Enrollment
92
Research Site
Aomori, Japan
Research Site
Bunkyō City, Japan
Research Site
Fujisawa, Japan
Research Site
Fukuoka, Japan
Research Site
Fukushima, Japan
Research Site
Hamamatsu, Japan
Research Site
Hiroshima, Japan
Research Site
Iizuka, Japan
Research Site
Izumo, Japan
Research Site
Kawasaki, Japan
...and 19 more locations
Mean change in ACQ-6 at week 52 from baseline
To estimate change of asthma control as measured by the ACQ-6 in patients who initiated Tezepelumab at week 52 from baseline
Time frame: Baseline and Week 52
Mean change in LCQ at week 52 from baseline
To estimate change of cough-specific health-related quality of life in patients who initiated Tezepelumab at week 52 from baseline
Time frame: Baseline and Week 52
Mean change in LCQ at week 4, 12, 24 from baseline
To estimate change of cough-specific health-related quality of life in patients who initiated Tezepelumab at week 4, 12, 24 from baseline
Time frame: Baseline, Week 4, Week 12 and Week 24
Mean change in ACQ-6 at week 4, 12, 24 from baseline
To estimate change of asthma control as measured by the ACQ-6 in patients who initiated Tezepelumab at week 4, 12, 24 from baseline
Time frame: Baseline, Week 4, Week 12 and Week 24
Asthma exacerbation rate during 52 weeks before/after Tezepelumab initiation Ratio of annual asthma exacerbation rate between previous 52 weeks and Tezepelumab treated 52 weeks
To estimate asthma exacerbation during 52 weeks before/after Tezepelumab initiation
Time frame: During 52 weeks before/after Tezepelumab initiation
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