The purpose of the study is to test a new video device for actinic keratoses. The device takes images of your skin lesions during the treatment, to learn whether this device can predict how well the treatment is working.
This intervention is designed to help establish what the optimal conditions are for treating actinic keratoses with photodynamic therapy (PDT). The primary outcome of this study is to determine whether the rate of singlet oxygen (sO2) production and/or the initial intralesional photosensitize (PpIX) levels, can predict the clinical responsiveness of AK lesions to PDT. Participants will receive standard red light PDT treatment, except that lesions will be carefully counted beforehand. During the window of red light illumination, photos and a video of one area of skin will be taken to allow us to monitor the progress of the treatment. Any remaining lesions will be counted upon follow-up.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
14
Topical Levulan Kerastick is applied to actinic keratoses.
PDT is a technique that combines a photosensitizing drug and an intense light source to kill tumor cells.
To occur post-PTD; used for activation of ALA during photodynamic therapy.
Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland, Ohio, United States
Lesion Clearance
Based on the rate of sO2 production, and/or the initial level of PpIX, is significantly correlated with the clinical responsiveness of AK lesions to PDT treatment. The clinical responsiveness will be measured by the decrease in the number of lesions
Time frame: 3 months post PDT treatment.
Noninvasive optical measurements of photosensitizer (PpIX) in lesions
To determine whether the initial level of PpIX can predict the clinical responsiveness of AK lesions to PDT treatment. The clinical responsiveness will be measured by the change in PpIX value before and after red light illumination.
Time frame: 3 months post PDT treatment.
Noninvasive optical measurements of singlet oxygen (sO2) in lesions.
To determine whether the rate of sO2 production can predict the clinical responsiveness of AK lesions to PDT treatment. The clinical responsiveness will be measured by the change in sO2 value before and after red light illumination.
Time frame: 3 months post PDT treatment.
Noninvasive optical measurements variability of photosensitizer (PpIX) in lesions
To characterize the variability in PpIX production between similarly-sized lesions. This will be measured by the accumulation of PpIX.
Time frame: 3 months post PDT treatment.
Noninvasive optical measurements variability of singlet oxygen (sO2) in lesions
To characterize the variability in sO2 generation between similarly-sized lesions, and to test whether production of sO2 during PDT correlates with the amount of photosensitizer available in AK lesions. This will be measured by sO2 production, measured in real-time by sO2 dosimeter.
Time frame: 3 months post PDT treatment.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.