Pro-rEsolving and pRo-inflammatory reSPonses to Acute exhaustIve exeRcisE in Healthy Individuals

Inclusion Criteria: * Willingness and ability to provide informed consent and participate in PRESPIRE * Able to read and speak English adequately to provide informed consent and understand verbal and written instructions. (the diet and sleep questionnaires are not validated in languages other than English) * BMI \< 27kg/m2 * Untrained: self-reporting no more than 1 day per week of regular exercise (inclusive of walking \>5,000 steps daily and commuting via bicycle). * Trained: self-reporting at least 4 hours of aerobic exercise / moderate or greater intensity physical activity weekly for the past year. Exclusion Criteria: * Anti-platelet medication use * Chronic inflammatory or connective tissue disease * History of bleeding or clotting disorder * Immunological deficiency * Diabetes mellitus * Stage 2 or greater hypertension on screening * Cardiovascular disease * Chronic obstructive lung disease * Anemia (hemoglobin \<13g/dL in males or \< 12 g/dL in females) * Active smoking * \>5% body weight change over the past 6 months or plan to gain/lose weight during the study * Platelet count \<100,000 * Use of omega-3 fatty acid supplementation within 3 weeks of study participation * Use of drugs or supplements known to inhibit COX-1/COX-2/lipoxygenases * Corticosteroid use * Use of beta-blocker medications * Use of alpha-blocker medications * Use of NSAIDs or aspirin within 2 weeks of study participation * Vaccination within 2 weeks of study participation * Pregnancy (a state of relative immunological deficiency) * Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric or other conditions that, in the opinion of the local clinician, would preclude participation and successful completion of the protocol. * Any other illnesses that, in the opinion of the local clinician, would negatively impact or mitigate participation in and completion of the protocol