The purpose of this study is to learn about the safety and tolerability of different doses of REGN17092 administered with a needle either under the skin (called "subcutaneous") or into a vein (called an "infusion") in healthy participants. This is the first time that REGN17092 will be given to people. Other aims are to assess: * How much of the study drug is in the blood at different times * Whether the body makes its own antibodies against the study drug (which could make the drug less effective or lead to side effects)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
Single ascending intravenous (IV) or subcutaneous (SC) administration per the protocol
Single ascending IV or SC administration per the protocol
UZ Leuven Gasthuisberg Campus
Leuven, Belgium
Occurrence of all treatment emergent adverse events (TEAEs)
Time frame: Through approximately day 365
Severity of all TEAEs
Time frame: Through approximately day 365
Occurrence of all treatment emergent serious adverse events (TE-SAEs)
Time frame: Through approximately day 365
Severity of all TE-SAEs
Time frame: Through approximately day 365
Concentrations of REGN17092 in serum over time
Time frame: Through approximately day 365
Incidence of Anti-drug antibodies (ADAs) to REGN17092 over time
Time frame: Through approximately day 365
Titer of ADAs to REGN17092 over time
Time frame: Through approximately day 365
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