Narcotic-Free Percutaneous Nephrolithotomy

Inclusion Criteria: * Undergoing scheduled unilateral standard (24Fr), PCNL with at least 2cm stone burden, with expected single access Exclusion Criteria: * Pregnant women * History of chronic opioid abuse * Allergy, hypersensitivity, or other contraindication to NSAID usage such as * eGFR \< 60 mL/min * Peptic ulcer disease or history of gastric bypass * Concurrent use of antiplatelet or anticoagulation therapy (including aspirin) * Thrombocytopenia * Suspected or confirmed cerebrovascular bleeding, patients with hemorrhagic diathesis, incomplete hemostasis, and those at high risk of bleeding. * Concomitant medications: * Other NSAIDs * Antiplatelet or anticoagulation medications * Probenecid * Pentoxifylline * Allergy, hypersensitivity, or other contraindication to opioids: * Current opioid prescription/usage for any reason, including active treatment with suboxone or methadone * Respiratory depression * Patients with acute or severe bronchial asthma or hypercarbia * Patients who have or is suspected of having paralytic ileus as PCNL done under general anesthesia * Patients with hepatic Impairment * Concomitant medications: * Monoamine Oxidase Inhibitors (MAOIs) * Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics * Diagnosis of chronic pain disorder * Reduced sensation of abdomen or pelvis (e.g. patients with spinal cord injury) * Pre-existing stent or nephrostomy tube * Urinary tract anomalies such as urinary diversion, horseshoe kidney, solitary kidney, urinary stricture disease, ureteropelvic junction obstruction, pelvic kidney, stone in calyceal diverticulum) * Pulmonary disease * Liver disease * Seizure disorders * Subjects taking nephrotoxic medications * Subjects taking medications that can increase sedation risk (benzodiazepines or other sedative hypnotics)