To study the efficacy and safety of finerenone in patients with primary aldosteronism
This is a prospective and randomized study involving patients with primary aldosteronism(PA). All paticipants will be randomized into finerenone group(Intervention group) and spironolactone group(Control group) and to compare the antihypertensive effect in patients with PA. If the self-measured blood pressure of patients at home continues to be greater than 140/90 mmHg at 2-4 weeks, spironolactone or finerenone should be increased to 40mg qd, and electrolytes should be reviewed at 2 weeks after dosed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Patients with PA divided into Intervention group need to take finerenone for 60 days (20mg qd).
The First Affilated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
Compare the change of daytime mean systolic blood pressure in the overall cohort between two groups.
Measured by ambulatory blood pressure monitoring
Time frame: At baseline and 2 month of follow-up
Compare the serum potassium elevation in the overall cohort between two groups.
Measured by blood electrolytes
Time frame: At baseline and 2 month of follow-up
Compare the change of daytime mean diastolic blood pressure in the overall cohort between two groups.
Measured by ambulatory blood pressure monitoring
Time frame: At baseline and 2 month of follow-up
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