The objective of this proposal is to investigate the acute effects of whole-body passive heat therapy using far-infrared technology on vascular function, exercise capacity, and renal function in CKD patients. The central hypothesis is that an acute bout of whole-body passive heat therapy will be well-tolerated and lead to acute improvements in large blood vessel (macrovascular) function, small blood vessel (microvascular) function, and exercise capacity without significantly altering markers of acute kidney injury.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
10
The whole-body passive heat therapy (HT) intervention will consist of an acute bout of infrared sauna for 25 minutes at 60°C. Participants will lie supine on a memory foam pad.
Participants will remain in a room temperature environment (22°C) underneath the infrared domes for 25 minutes.
Virginia Commonwealth University
Richmond, Virginia, United States
Renal Safety of Heat Therapy
Change in urinary NGAL
Time frame: Change from baseline to 90 minutes after intervention
Tolerability of Heat Therapy as Assessed using Validated Questionnaires of Thermal Perception
Self reported perception of heat using the the Thermal Sensation Scale.
Time frame: During 25 minute intervention
Conduit artery endothelial function
Brachial artery flow-mediated dilation assessed by high-resolution duplex ultrasound.
Time frame: 90 minutes after intervention
Lower Limb Microvascular Function
Lower limb microvascular function will be assessed with high-resolution duplex ultrasound during passive leg movement (PLM) technique.
Time frame: 90 minutes after intervention
Exercise Capacity
The 6-minute walk test distance.
Time frame: 90 minutes after intervention
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