The serum concentration of cartilage oligomeric matrix protein (sCOMP) has been considered a mechano-sensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP) is a proposed biomarker of type II collagen synthesis. Few studies have investigated both the anabolic and turnover response of articular cartilage as a result of acute changes in body weight mass during exercise. Using a repeated measures cross-over design, fifteen healthy adults (age 18-30 years) performed three, 30-minute bouts of treadmill walking exercise under 3 loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 minutes after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
15
Control (no alteration to body mass).
Loaded walking exercise (12% increase in body mass using a weighted vest).
Unloaded walking exercise (12% decrease in body mass using lower body positive pressure).
University of Manitoba
Winnipeg, Manitoba, Canada
Serum cartilage oligomeric matrix protein (sCOMP)
The systemic blood serum concentration of sCOMP was evaluated in all participants under the 3 conditions in a crossover trial.
Time frame: sCOMP was measured at baseline, immediately post, and 15- and 30-minutes post exercise.
N-propeptide of type II collagen (PIIANP)
The systemic blood serum concentration of PIIANP was evaluated in all participants under the 3 conditions in a crossover trial.
Time frame: PIIANP was measured at baseline, immediately post, and 15- and 30-minutes post exercise.
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