The goal of this clinical trial is to test microwave metamaterial glucose sensor on blood samples. It means to compare the results of glucose values obtained by microwave metamaterial sensor and by standard biochemical analyzer.
Participants will include physiological and pathological populations. Participants donate approximately 5 ml of blood sample. Three sample tubes will be collected from ten adult participants. In the first test tube, the blood glucose content will be determined by a validated biochemical analyzer (Roche, Switzerland). In the remaining volume of the blood sample, the dielectric parameters (relative permittivity and conductivity) will be estimated using a coaxial probe (Keysight, USA). Microwave metamaterial sensors with 5, 7 and 9 unit cells will be loaded with blood samples and the specific scattering matrices will be obtained using a vector network analyzer. The main monitored outcome measure will be the phase of parameter S21.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
21
Participant will donate approximately 5 ml blood sample. Later in a laboratory the sample will be processed in the microwave metamaterial sensor for non invasive blood glucose monitoring and standard biochemical analyzer. Specific dielectric properties and scattering parameters will be measured for blood glucose level determination.
Oblastní nemocnice Kladno, a.s.
Kladno, Central Bohemia, Czechia
Phase shift of scattering parameter S21
The proposed microwave sensor uses a section of planar metamaterial transmission line operating at GHz frequencies. The speed of electromagnetic wave propagation through the sample is affected by the concentration of glucose. The delay can be expressed in degrees (°) as the phase of the complex S21 parameter.
Time frame: When blood sample is filled into sensor chamber within 24 hours from blood collection.
Blood glucose concentration
Molar mass of glucose dissolved in liquid blood sample expressed as molar concentration (mmol/l).
Time frame: When blood sample is processed in biochemical analyzer within 24 hours from blood collection.
Blood sample specific electrical conductivity
The specific electrical conductivity (S/m) of the blood samples will be measured using a coaxial probe.
Time frame: When blood sample is presented into the co-axial probe container within 24 hours from blood collection.
Blood sample relative permittivity
The relative permittivity (-) of the blood samples will be measured using a coaxial probe.
Time frame: When blood sample is presented into the co-axial probe container within 24 hours from blood collection.
Sensor sensitivity
Present the relation between the value of he Phase shift of scattering parameter S21 and Blood glucose concentration.
Time frame: After primary data acqiusition.
Mathematical model of blood glucose dependence on blood dielectric parameters
The mathematical model describing which combination of dielectric parameter values (specific electrical conductivity and relative permittivity) corresponds to the certain blood glucose level.
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Time frame: After primary data acqiusition.