Observational Study of the Interaction Between Hepatitis C Virus Infection and Pregnancy

Beijing Ditan Hospital300 enrolled

Overview

The goal of this observational study is to learn about he effects of hepatitis C virus on pregnancy. The main question\[s\] it aims to answer are: Effect of hepatitis C virus on liver function in pregnant women Mother-to-child transmission rate in pregnant women with hepatitis C

This study aims to collect demographic data, biochemical indicators during pregnancy, pregnancy complications, and fetal outcomes through the hospital HIS and LIS systems to investigate the impact of HCV infection on pregnancy outcomes, mother-to-child transmission, and long-term child development, and to provide assistance in the clinical management of pregnant women with HCV infection.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Hepacivirus Pregnancy

Interventions

HCV infection statusOTHER

Divided into 3 groups based on HCVAb and HCVRNA status

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * normal (anti-HCV negative) or RNA negative (anti-HCV positive and HCV RNA negative) or RNA positive (anti-HCV positive and HCV RNA positive) pregnant women * pregnant women aged 20-45 years * complete pregnancy data available Exclusion Criteria: * Combination of other liver diseases such as viral hepatitis (hepatitis A, B, D, E), alcoholic hepatitis, autoimmune hepatitis, metabolic hepatitis, non-alcoholic fatty liver disease * Combination of other viral infections with potential loss of liver function * Mental illness * Patients with immunosuppression * Mother with cirrhosis or liver tumour

Locations (1)

Beijing Ditan Hospital

Beijing, China

Outcomes

Primary Outcomes

Incidence of various adverse pregnancy outcomes

The probability of postpartum haemorrhage, gestational diabetes mellitus and gestational hypertension in pregnant women infected with hepatitis C virus and the associated factors affecting them

Time frame: 2023-2025

Secondary Outcomes

Mother-to-child transmission rate of HCV

Mother-to-child transmission rate of HCV in pregnant women and correlation with HCV RNA viral load

Time frame: 2023-2025

Development of children born to HCV pregnant women

We will follow up on the child's weight (weight in kilograms）, heigh（height in meters）,Body mass index（BMI described in kg/m\^2) ,head circumference（Head circumference described in metres），Head up, roll over, sit, crawl, stand and talk start time（Describe time in months）.

Time frame: 2023-2025

Data from ClinicalTrials.gov

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