Endoscopic submucosal dissection (ESD) is the technique that has replaced surgery in the treatment of early neoplastic lesions of the stomach (LNPS). ESD of LNPS allows: a) less invasiveness compared to surgery; b) greater chances of "en bloc" resection and R0 resection compared to mucosectomy for lesions larger than 15 mm. Recent 2015 ESGE guidelines provide precise recommendations for the use of ESD in the treatment of LNPS, but Italy lacks prospective data on the efficacy and safety of ESD in a large sample of patients. A multicenter prospective observational study to create a database on the use of ESD in LNPS is essential to provide information regarding the efficacy and safety of ESD in Italy. This database would also provide information regarding the criteria applied in the use of ESD in the treatment of early gastric neoplasia
Study Type
OBSERVATIONAL
Enrollment
200
Endoscopic Submucosal Dissection
Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Italy
RECRUITINGEn bloc resection rate
removal of the lesion into a single piece.
Time frame: 10 years
R0 resection rate
complete removal of the tumor with histologically lateral and vertical margins of the specimen free from dysplasia
Time frame: 10 years
Curative resection rate
R0 resection with combined microstaging parameters not suggestive for high metastatic potential risk.
Time frame: 10 years
Complication rate
bleeding, perforation and stenosis.
Time frame: 10 years
Recurrence rate
dysplastic tissue at the site of resection at follow-up endoscopy.
Time frame: 10 years
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