Randomized Comparison of Skeletonized Versus Pedicled Left Internal Thoracic Artery

Inclusion criteria: Primary isolated CABG patients with multi-vessel disease (defined as ≥70 % stenosis of the left anterior descending artery (LAD) and ≥50% stenosis of circumflex and right coronary territory, with or without a ≥50% stenosis of the left main artery). Exclusion criteria: * Age \> 80 years * Planned CABG without LITA use * Preoperative mediastinal radiation therapy * Emergency operation * Minimal invasive coronary artery bypass surgery * Any concomitant cardiac or non-cardiac procedures * Previous cardiac surgery * Known contrast agent allergy * Severe stenosis of the left subclavian artery/ left-sided subclavian steal syndrome * Chronic kidney disease (GFR \<60ml/min/1.73m²) * Life expectancy of less than 5 years * Pregnancy * Hyperthyroidism * Iodine allergy Intraoperative exclusion criteria: * Y/T graft off the LITA graft * LITA sequential grafting * LITA target vessel other than LAD