This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.
This pilot study will establish low and high concentrations of both WS-3 and menthol concentrations to test in the main study. An anticipated 30 adult e-cigarette users will participate in one laboratory session during which participants will be exposed to e-liquids containing five different concentrations of two different cooling flavors without nicotine (10 e-liquids total). Participants will rate "coolness" using the generalized Labeled Magnitude Scale (gLMS). Using averages of participant ratings, we will select a low concentration of each constituent that is rated as more than "barely detectable" but less than "moderate" to ensure that cooling is weak but clearly perceptible. For the high concentration of each constituent, we will select a concentration that on average falls between "strong" and "very strong" to identify a strong cooling sensation while avoiding sensations that would also be uncomfortable.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
31
Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.05%.
Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.1%.
Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.5%.
Yale School of Medicine
New Haven, Connecticut, United States
Coolness: Score Change in Coolness of Each E-cigarette Condition (16 Conditions in Total)
Difference in overall flavor intensity, coolness, sweetness and harshness/irritation at each e-cigarette condition as measured by the computerized Generalized Labeled Magnitude Scale (gLMS). Participants will self-report their responses using a computer mouse to indicate where on the scale response falls. The Generalized Labeled Magnitude Scales (gLMS) are category ratio scales with seven semantic labels: "no sensation", "barely detectable", "weak", "moderate", "strong", "very strong", and "strongest imaginable", positioned quasi-logarithmically as per empirically determined semantic magnitudes on a 0-100 scale (strongest imaginable at the 100 end).
Time frame: Following administration of e-cigarette condition 1 (at 10 minutes), then 5 minutes post administration of each e-cigarette condition, up to 85 minutes (condition 16)
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Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 1.0%.
Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 2.0%.
Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.05%.
Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.1%.
Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.5%.
Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 1.0%.
Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 2.0%.
Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.05%.
Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.1%.
Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.5%.
Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 1.0%.
Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 2.0%.
Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 4.0%.