Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults

University of Malaya132 enrolled

Overview

The goal of this RCT is to compare the effectiveness of aminophylline and furosemide combination vs furosemide alone in producing effective diuresis in critically ill adults in ICU. ICU patients with the need of improved diuresis will be recruited and given either infusion of aminophylline and furosemide combination or furosemide alone, and their hourly urine output will be monitored to compare their effectiveness.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

132

Conditions

Acute Kidney Injury

Interventions

AminophyllineDRUG

aminophylline 150mg

FrusemideDRUG

frusemide 120mg

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18 years old and above who are admitted to the ICU of UMMC during the study period * Oliguric patients, with the need for improved diuresis at clinician discretion - defined as urine output \<0.5ml/kg/hour Exclusion Criteria: * Patient refusal for participation of study * Patients with known hypersensitivity reaction to aminophylline or furosemide * Patients with history of tachyarrhythmias, seizures, aspartate aminotransferase or alanine aminotransferase \> 3 times normal, or hypothyroidism. Patient with existing peptic ulcer disease or coagulopathy with INR \> 1.5

Locations (1)

University of Malaya

Kuala Lumpur, Malaysia

RECRUITING

Outcomes

Primary Outcomes

Percentage of patients with effective diuresis at 6 hours post intervention

whether effective diuresis is achieved at 6 hours post intervention. Effective diuresis is defined as urine output \>0.5ml/kg/hour based on patient's actual body weight

Time frame: 6 hours post intervention

Secondary Outcomes

Percentage of patients with effective diuresis at 2 hours post intervention

whether effective diuresis is achieved at 2 hours post intervention. Effective diuresis is defined as urine output \>0.5ml/kg/hour based on patient's actual body weight

Time frame: 2 hours post intervention

Mean duration of infusion to achieve effective diuresis post intervention

Time in hours taken for infusion to achieve effective diuresis post intervention. Effective diuresis is defined as urine output \>0.5ml/kg/hour based on patient's actual body weight

Time frame: Up to 6 hours post interventions

Changes in urine output at 6 hours post intervention

Difference of hourly urine output (ml/hour) measured immediately before starting intervention and 6 hours post intervention

Time frame: 6 hours post interventions

Changes in serum creatinine at 1 day post intervention

Difference of serum creatinine in mmol/l on the day of intervention and one day after intervention

Time frame: 1 day post intervention

Changes in serum eGFR at 1 day post intervention

Difference of serum eGFR in mL/min/1.73m2 on the day of intervention and one day after intervention

Time frame: 1 day post intervention

Central Contacts

Haw Shyan Ng

CONTACT

+6 016 483 7722 plue_chris@yahoo.co.uk

Data from ClinicalTrials.gov

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