Biocollection on Peripheral Inflammation

Nantes University Hospital300 enrolled

Overview

Most psychiatric research is based on the nosographic classifications used in current practice. At present, there is no diagnostic or prognostic biomarker for psychiatric pathologies commonly used in clinical practice. The study hypothesis is that peripheral inflammatory biomarkers could be common to several psychiatric disorders, in particular psychotic disorders (bipolar disorder, schizophreniform disorder, schizophrenia, depressive episode with psychotic features). The aim of this project is to set up a bio-collection of biological samples (peripheral blood samples) with associated phenotypic data (assessment of various symptoms using standardized scales in patients whose blood is sampled). The setting up of this cohort follows on from work carried out on a PsyCourse cohort also using a transdiagnostic approach in psychiatry, in order to be able to collaborate within a European research project.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Schizoaffective Disorder, Depressive Type Bipolar Disorder I Bipolar Disorder II

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Major patient * Patient with one of the following diagnoses confirmed by a psychiatrist: * Characterized depressive episode with psychotic features, * Bipolar disorder type I * Bipolar disorder type II * Schizoaffective disorder * Schizophrenia * Schizophreniform disorder * Patient under psychiatric care at Nantes University Hospital * Patients weighing at least 45kg * Patient affiliated to a social security scheme or beneficiary of such a scheme * Patient who has given informed consent to participate in the study Exclusion Criteria: * Pregnant, * History of cancer in the last 5 years, * Vaccination within the last 4 weeks, * Acute or chronic infection, * Medical history of organ transplant, * Medical history of autoimmune disease, * Hearing impairment making it impossible to complete study questionnaires, * Patient under court protection

Outcomes

Primary Outcomes

Demonstration of the presence of diagnostic biomarkers and biomarkers of severity common to several psychiatric disorders.

Biological analysis of IBIS-PSY biocollection samples

Time frame: 2 hours

Secondary Outcomes

Validation of a patient clustering method separating patients with severe symptoms from those with mild symptoms

Time frame: 2 hours

Replication of a pan-transcriptomic study (A Transcriptome-Wide Association Study (TWAS))

Time frame: 2 hours

Comparison of biomarkers between different psychiatric illnesses in order to develop models based on biological data that can help the physician adjust the diagnosis

Time frame: 2 hours

Biocollection on Peripheral Inflammation

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts