Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis

Overview

This observatory aims to collect, as widely as possible, the Italian cases of patients with uncontrolled CRS. Patient will be enrolled by the centers of the Italian Network of Rhinosinusitis (Rhinosinusitis Italian Network: RINET), and they will be treated using a multidisciplinary team approach (allergists, otolaryngologists and pneumologists) in a real-world clinical set-up. This real-life chronic rhinosinusitis registry aims at longitudinal data collection from patients attending specialist care centres across Italy.

The primary objectives of the study are: * to characterize and to describe the evolution of uncontrolled Chronic Rhinosinusitis (CRS); * to facilitate and to characterize the phenotyping and endotyping of CRS; * studying the efficacy and safety of the principal therapeutic strategies and approaches to uncontrolled CRS in real-life; * supporting the development of diagnostic methodologies and innovative therapeutic strategies for CRS; * to evaluate the clinical and economic-health impact of the different therapeutic approaches (including systemic corticosteroids) used for uncontrolled CRS; * to describe factors associated with therapeutic choices and how much this factors influence natural history of the CRS; * Studying and identifying biomarkers and predictors of response to different therapies; * to increase the "awareness" of CRS in patients, in public opinion, in the national and international scientific community, and in the Italian clinical community of the otolaryngologists, the allergists and the pneumologists.

Conditions

Interventions