Postoperative Effects of Propofol Versus Sevoflurane Anesthesia

Damanhour Teaching Hospital44 enrolled

Overview

Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life. Objectives: To compare the efficacy and safety of propofol versus sevoflurane in patients undergoing elective, non-cardiac operations under general anesthesia. Methods: This was a randomized (1:1), parallel, phase four clinical trial; carried out on 44 patients, who were candidates for elective, non-cardiac operations under general anesthesia at our hospital. Patients were randomly allocated into two equal groups in which anesthesia was maintained with propofol infusion in group P and sevoflurane inhalation in group S.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

Conditions

General Anesthetic Drug Adverse Reaction

Interventions

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status ≤ II * Age from 21 years * Body Mass Index (BMI) 25-35 kg/m2 Exclusion Criteria: * ASA physical status \> II * Age \< 21 years * Patients with Montreal Objective Cognitive Assessment (MoCA-B) score \< 24 points * Patients with significant cardiovascular, cerebrovascular, respiratory, liver, renal, endocrine, blood, or immune diseases * Patients with visual or auditory disease, infection, chronic inflammation, disturbance of consciousness, cognitive impairment, or dementia * Patients on long-term use of sedatives or steroids, alcohol or drug abuse * Allergy to any of the study drugs

Outcomes

Primary Outcomes

Mean and Standard deviation of Neuron Specific Enolase enzyme (µg/L) in blood serum (mean±SD)

Before operation (T0), 1 hour after the end of operation (T1), 24 hours the end of operation (T2)

Time frame: 24 hours after the end of operation