The main purpose of this study is to investigate the effect of retatrutide on renal function in participants with overweight or obesity and chronic kidney disease (CKD), with or without Type 2 Diabetes (T2D). The study will last around 31 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
146
Administered SC
Administered SC
Change from Baseline in Glomerular Filtration Rate (mGFR)
The GFR in milliliter/minute per1.73 square meter (mL/min/1.73 m²) using iohexol clearance (mGFR-measured glomerular filtration rate)
Time frame: Baseline, Week 24
Change from Baseline in Urine Albumin-to-Creatinine Ratio (UACR)
Time frame: Baseline, Week 24
Change from Baseline in Creatinine-Corrected Fractional Urinary Sodium Excretion (FENa)
Time frame: Baseline, Week 24
Change from Baseline in Filtration Fraction Estimated from Measured Glomerular Filtration Rate (mGFR)
Time frame: Baseline, Week 24
Change from Baseline in Renal Mean Arterial Flow as Assessed by Magnetic Resonance Imaging (MRI), Corrected by Hematocrit
Time frame: Baseline, Week 24
Change from Baseline in in Mean Arterial Flow (MAF)
Time frame: Baseline, Week 24
Change from Baseline in Renal Artery Resistive Index (RARI)
Time frame: Baseline, Week 24
Change from Baseline in Renal Blood Flow Velocity Peak Systolic Velocity (PSV) and End-diastolic Velocity (ESV)
Time frame: Baseline, Week 24
Change from Baseline in Global Renal Perfusion (MRI)
Time frame: Baseline, Week 24
Change from Baseline in Total Renal Parenchyma Volume (MRI)
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The Institute for Liver Health II dba Arizona Clinical Trials - Mesa
Chandler, Arizona, United States
Care Access - 801 South Power Road, Mesa
Mesa, Arizona, United States
Headlands Research - Scottsdale
Scottsdale, Arizona, United States
Medical Advancement Centers of Arizona
Tempe, Arizona, United States
Hope Clinical Research, Inc.
Canoga Park, California, United States
Catalina Research Institute, LLC
Montclair, California, United States
Peninsula Research Associates
Rolling Hills Estates, California, United States
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Teradan Clinical Trials, LLC
Brandon, Florida, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
...and 32 more locations
Time frame: Baseline, Week 24
Change from Baseline in Renal Cortex Volume (MRI)
Time frame: Baseline, Week 24
Change from Baseline in Renal Cortex T1 (ms) (MRI)
Time frame: Baseline, Week 24
Change from Baseline in Medulla T1 (ms) (MRI)
Time frame: Baseline, Week 24
Change from Baseline in Renal Cortex R2 (BOLD MRI)
Time frame: Baseline, Week 24
Change from Baseline in Medulla R2
Time frame: Baseline, Week 24
Change from Baseline in Body Weight
Time frame: Baseline, Week 24
Change from Baseline in 24-hr Urinary Albumin Excretion (UAE)
Time frame: Baseline, Week 24
Change from Baseline in Change in 24-hour (hr) Urinary Electrolytes (milligrams/24hr (mg/24h))
Time frame: Baseline, Week 24