Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer Survivorship

Inclusion Criteria: * Participants must be 18 years of age or older * Participants must have previously been diagnosed with head and neck cancer and undergone surgery and radiation as part of their standard-of-care treatment plan * Participants must be ≥ 4 weeks but less than 3 months post-radiation therapy at enrollment * Female participants of childbearing potential must have a negative urine pregnancy test ≤ 36 hours prior to study drug administration * Female participants of childbearing potential must agree to use a medically accepted method of contraception for a period of one month after each imaging session * Male participants must agree to shave facial hair on imaging days * Participants must be willing and able to independently use the pneumatic compression device at home daily for up to 12 months as directed by study personnel. Exclusion Criteria: * Persons who are pregnant or breast-feeding * Females of child-bearing potential, who do not agree to use an approved contraceptive for one month after each imaging session * Persons who do not meet inclusion criteria * Iodine allergy * Persons with a chest circumference of 150 cm or more * Uncontrolled hyperthyroidism or parathyroidism (for which an endocrinologist recommends against neck compression) * Carotid sinus hypersensitivity syndrome * Symptomatic carotid artery disease, as manifested by a recent transient ischemic attack (within 30 days), ischemic stroke or amaurosis fugax (monocular visual ischemic symptoms or blindness) * Symptomatic bradycardia in the absence of a pacemaker or internal jugular venous thrombosis (within 3 months) * Increased intracranial pressure or other contraindication to internal or external jugular venous compression * Acute radiation dermatitis, unhealed surgical scar, unhealed or open wound(s), surgical flap less than 6 to 8-weeks post-operative * Facial or head and neck dermal metastasis * Acute facial infection (e.g., facial, or parotid gland abscess) * Heart failure (acute pulmonary edema, decompensated acute heart failure) * Acute venous disease (acute thrombophlebitis, acute deep venous thrombosis, acute pulmonary embolism) * Severe peripheral artery disease (critical limb ischemia including ischemic rest pain, arterial wounds, or gangrene) * Active skin or limb infection/inflammatory disease (acute cellulitis, other uncontrolled skin, or untreated inflammatory skin disease) * Any condition where increased venous and lymphatic return is undesirable