Low Concentration Atropine in the Prevention of Myopia in Children.

Inclusion Criteria: 1. The age of the screening stage is 6-9 years, both sexes; 2. One eye met the diagnosis of pre-myopia, the spherical equivalent was between -0.50D and +0.75D, the astigmatism was ≥-1.50D, and the best corrected far vision was at least 1.0; 3. At least one of parents suffers from myopia (SE of at least one eye \<=-3.00D); 4. Parents have signed informed consent and agree to participate in screening and follow-up. Exclusion Criteria: 1. Parents disagree to sign the informed consent; 2. Presence of strabismus, amblyopia, or other ocular abnormalities, or have a history of eye surgery; 3. Presence of other eye or systemic diseases; 4. Allergies to low concentration atropine or sulfuric acid drugs; 5. Histories of using other preventive measures, such as using red light within 6 months or atropine within 1 month; 6. Presence of other situations that the researchers think is not appropriate for patients to be included in the project.